Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease

Transient aneuploidy enables cells to survive sudden environmental changes before longterm cellular adaptations are established. Here, the authors show that yeast cells respond to the acute loss of Ulp2 SUMO protease by rapid induction of aneuploidy, and reveal predictable long-term adaptation mecha...

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Autores principales:	Hong-Yeoul Ryu, Francesc López-Giráldez, James Knight, Soo Seok Hwang, Christina Renner, Stefan G. Kreft, Mark Hochstrasser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa07ec2c498048edae01417a7f9d5564
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spelling	oai:doaj.org-article:fa07ec2c498048edae01417a7f9d55642021-12-02T16:56:54ZDistinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease10.1038/s41467-018-07836-02041-1723https://doaj.org/article/fa07ec2c498048edae01417a7f9d55642018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07836-0https://doaj.org/toc/2041-1723Transient aneuploidy enables cells to survive sudden environmental changes before longterm cellular adaptations are established. Here, the authors show that yeast cells respond to the acute loss of Ulp2 SUMO protease by rapid induction of aneuploidy, and reveal predictable long-term adaptation mechanisms that restore euploidy.Hong-Yeoul RyuFrancesc López-GiráldezJames KnightSoo Seok HwangChristina RennerStefan G. KreftMark HochstrasserNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hong-Yeoul Ryu Francesc López-Giráldez James Knight Soo Seok Hwang Christina Renner Stefan G. Kreft Mark Hochstrasser Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
description	Transient aneuploidy enables cells to survive sudden environmental changes before longterm cellular adaptations are established. Here, the authors show that yeast cells respond to the acute loss of Ulp2 SUMO protease by rapid induction of aneuploidy, and reveal predictable long-term adaptation mechanisms that restore euploidy.
format	article
author	Hong-Yeoul Ryu Francesc López-Giráldez James Knight Soo Seok Hwang Christina Renner Stefan G. Kreft Mark Hochstrasser
author_facet	Hong-Yeoul Ryu Francesc López-Giráldez James Knight Soo Seok Hwang Christina Renner Stefan G. Kreft Mark Hochstrasser
author_sort	Hong-Yeoul Ryu
title	Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
title_short	Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
title_full	Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
title_fullStr	Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
title_full_unstemmed	Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
title_sort	distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the ulp2 sumo protease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fa07ec2c498048edae01417a7f9d5564
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Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease

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