KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

The mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) are transcription factors that govern metabolic homeostasis in various organs. Many KLFs show a circadian expressio...

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Autores principales:	Anthony A Ruberto, Aline Gréchez-Cassiau, Sophie Guérin, Luc Martin, Johana S Revel, Mohamed Mehiri, Malayannan Subramaniam, Franck Delaunay, Michèle Teboul
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	circadian rhythm metabolism krüppel like factors liver fructose glucose Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fa08fc0906c94393808804c0ab741b9b
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spelling	oai:doaj.org-article:fa08fc0906c94393808804c0ab741b9b2021-11-16T14:02:16ZKLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism10.7554/eLife.655742050-084Xe65574https://doaj.org/article/fa08fc0906c94393808804c0ab741b9b2021-08-01T00:00:00Zhttps://elifesciences.org/articles/65574https://doaj.org/toc/2050-084XThe mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) are transcription factors that govern metabolic homeostasis in various organs. Many KLFs show a circadian expression in the liver. Here, we show that the loss of the clock-controlled KLF10 in hepatocytes results in extensive reprogramming of the mouse liver circadian transcriptome, which in turn alters the temporal coordination of pathways associated with energy metabolism. We also show that glucose and fructose induce Klf10, which helps mitigate glucose intolerance and hepatic steatosis in mice challenged with a sugar beverage. Functional genomics further reveal that KLF10 target genes are primarily involved in central carbon metabolism. Together, these findings show that in the liver KLF10 integrates circadian timing and sugar metabolism-related signaling, and serves as a transcriptional brake that protects against the deleterious effects of increased sugar consumption.Anthony A RubertoAline Gréchez-CassiauSophie GuérinLuc MartinJohana S RevelMohamed MehiriMalayannan SubramaniamFranck DelaunayMichèle TebouleLife Sciences Publications Ltdarticlecircadian rhythmmetabolismkrüppel like factorsliverfructoseglucoseMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circadian rhythm metabolism krüppel like factors liver fructose glucose Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	circadian rhythm metabolism krüppel like factors liver fructose glucose Medicine R Science Q Biology (General) QH301-705.5 Anthony A Ruberto Aline Gréchez-Cassiau Sophie Guérin Luc Martin Johana S Revel Mohamed Mehiri Malayannan Subramaniam Franck Delaunay Michèle Teboul KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
description	The mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) are transcription factors that govern metabolic homeostasis in various organs. Many KLFs show a circadian expression in the liver. Here, we show that the loss of the clock-controlled KLF10 in hepatocytes results in extensive reprogramming of the mouse liver circadian transcriptome, which in turn alters the temporal coordination of pathways associated with energy metabolism. We also show that glucose and fructose induce Klf10, which helps mitigate glucose intolerance and hepatic steatosis in mice challenged with a sugar beverage. Functional genomics further reveal that KLF10 target genes are primarily involved in central carbon metabolism. Together, these findings show that in the liver KLF10 integrates circadian timing and sugar metabolism-related signaling, and serves as a transcriptional brake that protects against the deleterious effects of increased sugar consumption.
format	article
author	Anthony A Ruberto Aline Gréchez-Cassiau Sophie Guérin Luc Martin Johana S Revel Mohamed Mehiri Malayannan Subramaniam Franck Delaunay Michèle Teboul
author_facet	Anthony A Ruberto Aline Gréchez-Cassiau Sophie Guérin Luc Martin Johana S Revel Mohamed Mehiri Malayannan Subramaniam Franck Delaunay Michèle Teboul
author_sort	Anthony A Ruberto
title	KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
title_short	KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
title_full	KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
title_fullStr	KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
title_full_unstemmed	KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
title_sort	klf10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/fa08fc0906c94393808804c0ab741b9b
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_version_	1718426459577516032

KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

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