Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer

Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer

Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.

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Autores principales: Joanna Achinger-Kawecka, Fatima Valdes-Mora, Phuc-Loi Luu, Katherine A. Giles, C. Elizabeth Caldon, Wenjia Qu, Shalima Nair, Sebastian Soto, Warwick J. Locke, Nicole S. Yeo-Teh, Cathryn M. Gould, Qian Du, Grady C. Smith, Irene R. Ramos, Kristine F. Fernandez, Dave S. Hoon, Julia M. W. Gee, Clare Stirzaker, Susan J. Clark
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/fa0958eacf7f42d19237b40a66d1a2d1
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spelling oai:doaj.org-article:fa0958eacf7f42d19237b40a66d1a2d12021-12-02T14:40:27ZEpigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer10.1038/s41467-019-14098-x2041-1723https://doaj.org/article/fa0958eacf7f42d19237b40a66d1a2d12020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14098-xhttps://doaj.org/toc/2041-1723Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.Joanna Achinger-KaweckaFatima Valdes-MoraPhuc-Loi LuuKatherine A. GilesC. Elizabeth CaldonWenjia QuShalima NairSebastian SotoWarwick J. LockeNicole S. Yeo-TehCathryn M. GouldQian DuGrady C. SmithIrene R. RamosKristine F. FernandezDave S. HoonJulia M. W. GeeClare StirzakerSusan J. ClarkNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Joanna Achinger-Kawecka
Fatima Valdes-Mora
Phuc-Loi Luu
Katherine A. Giles
C. Elizabeth Caldon
Wenjia Qu
Shalima Nair
Sebastian Soto
Warwick J. Locke
Nicole S. Yeo-Teh
Cathryn M. Gould
Qian Du
Grady C. Smith
Irene R. Ramos
Kristine F. Fernandez
Dave S. Hoon
Julia M. W. Gee
Clare Stirzaker
Susan J. Clark
Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer
description Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.
format article
author Joanna Achinger-Kawecka
Fatima Valdes-Mora
Phuc-Loi Luu
Katherine A. Giles
C. Elizabeth Caldon
Wenjia Qu
Shalima Nair
Sebastian Soto
Warwick J. Locke
Nicole S. Yeo-Teh
Cathryn M. Gould
Qian Du
Grady C. Smith
Irene R. Ramos
Kristine F. Fernandez
Dave S. Hoon
Julia M. W. Gee
Clare Stirzaker
Susan J. Clark
author_facet Joanna Achinger-Kawecka
Fatima Valdes-Mora
Phuc-Loi Luu
Katherine A. Giles
C. Elizabeth Caldon
Wenjia Qu
Shalima Nair
Sebastian Soto
Warwick J. Locke
Nicole S. Yeo-Teh
Cathryn M. Gould
Qian Du
Grady C. Smith
Irene R. Ramos
Kristine F. Fernandez
Dave S. Hoon
Julia M. W. Gee
Clare Stirzaker
Susan J. Clark
author_sort Joanna Achinger-Kawecka
title Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer
title_short Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer
title_full Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer
title_fullStr Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer
title_full_unstemmed Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer
title_sort epigenetic reprogramming at estrogen-receptor binding sites alters 3d chromatin landscape in endocrine-resistant breast cancer
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/fa0958eacf7f42d19237b40a66d1a2d1
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