A fresh look at the origin of Plasmodium falciparum, the most malignant malaria agent.

From which host did the most malignant human malaria come: birds, primates, or rodents? When did the transfer occur? Over the last half century, these have been some of the questions up for debate about the origin of Plasmodium falciparum, the most common and deadliest human malaria parasite, which...

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Autores principales: Franck Prugnolle, Patrick Durand, Benjamin Ollomo, Linda Duval, Frédéric Ariey, Céline Arnathau, Jean-Paul Gonzalez, Eric Leroy, François Renaud
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Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/fa0ab5d4c2744cebb09401077aa6f084
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spelling oai:doaj.org-article:fa0ab5d4c2744cebb09401077aa6f0842021-11-18T06:03:34ZA fresh look at the origin of Plasmodium falciparum, the most malignant malaria agent.1553-73661553-737410.1371/journal.ppat.1001283https://doaj.org/article/fa0ab5d4c2744cebb09401077aa6f0842011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21383971/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374From which host did the most malignant human malaria come: birds, primates, or rodents? When did the transfer occur? Over the last half century, these have been some of the questions up for debate about the origin of Plasmodium falciparum, the most common and deadliest human malaria parasite, which is responsible for at least one million deaths every year. Recent findings bring elements in favor of a transfer from great apes, but are these evidences really solid? What are the grey areas that remain to be clarified? Here, we examine in depth these new elements and discuss how they modify our perception of the origin and evolution of P. falciparum. We also discuss the perspectives these new discoveries open.Franck PrugnollePatrick DurandBenjamin OllomoLinda DuvalFrédéric ArieyCéline ArnathauJean-Paul GonzalezEric LeroyFrançois RenaudPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 2, p e1001283 (2011)
institution DOAJ
collection DOAJ
language EN
topic Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
spellingShingle Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Franck Prugnolle
Patrick Durand
Benjamin Ollomo
Linda Duval
Frédéric Ariey
Céline Arnathau
Jean-Paul Gonzalez
Eric Leroy
François Renaud
A fresh look at the origin of Plasmodium falciparum, the most malignant malaria agent.
description From which host did the most malignant human malaria come: birds, primates, or rodents? When did the transfer occur? Over the last half century, these have been some of the questions up for debate about the origin of Plasmodium falciparum, the most common and deadliest human malaria parasite, which is responsible for at least one million deaths every year. Recent findings bring elements in favor of a transfer from great apes, but are these evidences really solid? What are the grey areas that remain to be clarified? Here, we examine in depth these new elements and discuss how they modify our perception of the origin and evolution of P. falciparum. We also discuss the perspectives these new discoveries open.
format article
author Franck Prugnolle
Patrick Durand
Benjamin Ollomo
Linda Duval
Frédéric Ariey
Céline Arnathau
Jean-Paul Gonzalez
Eric Leroy
François Renaud
author_facet Franck Prugnolle
Patrick Durand
Benjamin Ollomo
Linda Duval
Frédéric Ariey
Céline Arnathau
Jean-Paul Gonzalez
Eric Leroy
François Renaud
author_sort Franck Prugnolle
title A fresh look at the origin of Plasmodium falciparum, the most malignant malaria agent.
title_short A fresh look at the origin of Plasmodium falciparum, the most malignant malaria agent.
title_full A fresh look at the origin of Plasmodium falciparum, the most malignant malaria agent.
title_fullStr A fresh look at the origin of Plasmodium falciparum, the most malignant malaria agent.
title_full_unstemmed A fresh look at the origin of Plasmodium falciparum, the most malignant malaria agent.
title_sort fresh look at the origin of plasmodium falciparum, the most malignant malaria agent.
publisher Public Library of Science (PLoS)
publishDate 2011
url https://doaj.org/article/fa0ab5d4c2744cebb09401077aa6f084
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