Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance

Abstract To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svRT and PAL results were combined with 22 survey ques...

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Autores principales:	J. S. Talboom, M. D. De Both, M. A. Naymik, A. M. Schmidt, C. R. Lewis, W. M. Jepsen, A. K. Håberg, T. Rundek, B. E. Levin, S. Hoscheidt, Y. Bolla, R. D. Brinton, N. J. Schork, M. Hay, C. A. Barnes, E. Glisky, L. Ryan, M. J. Huentelman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/fa0aca7984c542429f315df100c18eec
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spelling	oai:doaj.org-article:fa0aca7984c542429f315df100c18eec2021-12-02T18:18:31ZTwo separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance10.1038/s41514-021-00067-62056-3973https://doaj.org/article/fa0aca7984c542429f315df100c18eec2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41514-021-00067-6https://doaj.org/toc/2056-3973Abstract To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svRT and PAL results were combined with 22 survey questions. Analysis of svRT revealed education and stroke as potential modifiers of changes in processing speed and memory from younger to older ages (n total = 75,666, n women = 47,700, n men = 27,966; ages 18–85 years old, mean (M)Age = 46.54, standard deviation (SD) Age = 18.40). To complement this work, we evaluated complex visual recognition reaction time (cvrRT) in the UK Biobank (n total = 158,249 n women = 89,333 n men = 68,916; ages 40–70 years old, M Age = 55.81, SDAge = 7.72). Similarities between the UK Biobank and MindCrowd were assessed using a subset of MindCrowd (UKBb MindCrowd) selected to mirror the UK Biobank demographics (n total = 39,795, n women = 29,640, n men = 10,155; ages 40–70 years old, M Age = 56.59, SDAge = 8.16). An identical linear model (LM) was used to assess both cohorts. Analyses revealed similarities between MindCrowd and the UK Biobank across most results. Divergent findings from the UK Biobank included (1) a first-degree family history of Alzheimer’s disease (FHAD) was associated with longer cvrRT. (2) Men with the least education were associated with longer cvrRTs comparable to women across all educational attainment levels. Divergent findings from UKBb MindCrowd included more education being associated with shorter svRTs and a history of smoking with longer svRTs from younger to older ages.J. S. TalboomM. D. De BothM. A. NaymikA. M. SchmidtC. R. LewisW. M. JepsenA. K. HåbergT. RundekB. E. LevinS. HoscheidtY. BollaR. D. BrintonN. J. SchorkM. HayC. A. BarnesE. GliskyL. RyanM. J. HuentelmanNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 J. S. Talboom M. D. De Both M. A. Naymik A. M. Schmidt C. R. Lewis W. M. Jepsen A. K. Håberg T. Rundek B. E. Levin S. Hoscheidt Y. Bolla R. D. Brinton N. J. Schork M. Hay C. A. Barnes E. Glisky L. Ryan M. J. Huentelman Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance
description	Abstract To identify potential factors influencing age-related cognitive decline and disease, we created MindCrowd. MindCrowd is a cross-sectional web-based assessment of simple visual (sv) reaction time (RT) and paired-associate learning (PAL). svRT and PAL results were combined with 22 survey questions. Analysis of svRT revealed education and stroke as potential modifiers of changes in processing speed and memory from younger to older ages (n total = 75,666, n women = 47,700, n men = 27,966; ages 18–85 years old, mean (M)Age = 46.54, standard deviation (SD) Age = 18.40). To complement this work, we evaluated complex visual recognition reaction time (cvrRT) in the UK Biobank (n total = 158,249 n women = 89,333 n men = 68,916; ages 40–70 years old, M Age = 55.81, SDAge = 7.72). Similarities between the UK Biobank and MindCrowd were assessed using a subset of MindCrowd (UKBb MindCrowd) selected to mirror the UK Biobank demographics (n total = 39,795, n women = 29,640, n men = 10,155; ages 40–70 years old, M Age = 56.59, SDAge = 8.16). An identical linear model (LM) was used to assess both cohorts. Analyses revealed similarities between MindCrowd and the UK Biobank across most results. Divergent findings from the UK Biobank included (1) a first-degree family history of Alzheimer’s disease (FHAD) was associated with longer cvrRT. (2) Men with the least education were associated with longer cvrRTs comparable to women across all educational attainment levels. Divergent findings from UKBb MindCrowd included more education being associated with shorter svRTs and a history of smoking with longer svRTs from younger to older ages.
format	article
author	J. S. Talboom M. D. De Both M. A. Naymik A. M. Schmidt C. R. Lewis W. M. Jepsen A. K. Håberg T. Rundek B. E. Levin S. Hoscheidt Y. Bolla R. D. Brinton N. J. Schork M. Hay C. A. Barnes E. Glisky L. Ryan M. J. Huentelman
author_facet	J. S. Talboom M. D. De Both M. A. Naymik A. M. Schmidt C. R. Lewis W. M. Jepsen A. K. Håberg T. Rundek B. E. Levin S. Hoscheidt Y. Bolla R. D. Brinton N. J. Schork M. Hay C. A. Barnes E. Glisky L. Ryan M. J. Huentelman
author_sort	J. S. Talboom
title	Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance
title_short	Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance
title_full	Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance
title_fullStr	Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance
title_full_unstemmed	Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance
title_sort	two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa0aca7984c542429f315df100c18eec
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Two separate, large cohorts reveal potential modifiers of age-associated variation in visual reaction time performance

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