Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population

Abstract Recent studies in animal models and humans show that long non-coding RNAs (lncRNAs) are involved in the development of atherosclerosis, which contributes to the pathological foundation of coronary artery disease (CAD). LncRNAs in plasma and serum have been considered as promising novel biom...

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Autores principales:	Zhen Zhang, Wei Gao, Qing-Qing Long, Jian Zhang, Ya-Fei Li, Dong-Chen liu, Jian-Jun Yan, Zhi-Jian Yang, Lian-Sheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa0bfdf3678645eeaeb14fef43225a16
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spelling	oai:doaj.org-article:fa0bfdf3678645eeaeb14fef43225a162021-12-02T16:06:50ZIncreased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population10.1038/s41598-017-07611-z2045-2322https://doaj.org/article/fa0bfdf3678645eeaeb14fef43225a162017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07611-zhttps://doaj.org/toc/2045-2322Abstract Recent studies in animal models and humans show that long non-coding RNAs (lncRNAs) are involved in the development of atherosclerosis, which contributes to the pathological foundation of coronary artery disease (CAD). LncRNAs in plasma and serum have been considered as promising novel biomarkers for diagnosis and prognosis of cardiovascular diseases, especially CAD. We here measured the circulating levels of 8 individual lncRNAs which are known to be relevant to atherosclerosis in the plasma samples from 300 patients with CAD and 180 control subjects by using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) methods. We found that the plasma level of H19 and long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) were significantly increased in patients with CAD. The area under the receiver operating characteristic curve was 0.631 for H19 and 0.722 for LIPCAR. Multivariate logistic regression analyses indicated that plasma H19 and LIPCAR were independent predictors for CAD, even after adjustment for traditional cardiovascular risk factors. Further studies identified that plasma levels of H19 and LIPCAR were also increased in CAD patients with heart failure compared to those with normal cardiac function. Taken together, our results suggest that increased plasma levels of H19 and LIPCAR are associated with increased risk of CAD and may be considered as novel biomarkers for CAD.Zhen ZhangWei GaoQing-Qing LongJian ZhangYa-Fei LiDong-Chen liuJian-Jun YanZhi-Jian YangLian-Sheng WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhen Zhang Wei Gao Qing-Qing Long Jian Zhang Ya-Fei Li Dong-Chen liu Jian-Jun Yan Zhi-Jian Yang Lian-Sheng Wang Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population
description	Abstract Recent studies in animal models and humans show that long non-coding RNAs (lncRNAs) are involved in the development of atherosclerosis, which contributes to the pathological foundation of coronary artery disease (CAD). LncRNAs in plasma and serum have been considered as promising novel biomarkers for diagnosis and prognosis of cardiovascular diseases, especially CAD. We here measured the circulating levels of 8 individual lncRNAs which are known to be relevant to atherosclerosis in the plasma samples from 300 patients with CAD and 180 control subjects by using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) methods. We found that the plasma level of H19 and long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) were significantly increased in patients with CAD. The area under the receiver operating characteristic curve was 0.631 for H19 and 0.722 for LIPCAR. Multivariate logistic regression analyses indicated that plasma H19 and LIPCAR were independent predictors for CAD, even after adjustment for traditional cardiovascular risk factors. Further studies identified that plasma levels of H19 and LIPCAR were also increased in CAD patients with heart failure compared to those with normal cardiac function. Taken together, our results suggest that increased plasma levels of H19 and LIPCAR are associated with increased risk of CAD and may be considered as novel biomarkers for CAD.
format	article
author	Zhen Zhang Wei Gao Qing-Qing Long Jian Zhang Ya-Fei Li Dong-Chen liu Jian-Jun Yan Zhi-Jian Yang Lian-Sheng Wang
author_facet	Zhen Zhang Wei Gao Qing-Qing Long Jian Zhang Ya-Fei Li Dong-Chen liu Jian-Jun Yan Zhi-Jian Yang Lian-Sheng Wang
author_sort	Zhen Zhang
title	Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population
title_short	Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population
title_full	Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population
title_fullStr	Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population
title_full_unstemmed	Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population
title_sort	increased plasma levels of lncrna h19 and lipcar are associated with increased risk of coronary artery disease in a chinese population
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fa0bfdf3678645eeaeb14fef43225a16
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Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population

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