Improving proton therapy by metal-containing nanoparticles: nanoscale insights

Thomas Schlathölter,1 Pierre Eustache,2 Erika Porcel,2 Daniela Salado,2 Lenka Stefancikova,2 Olivier Tillement,3 Francois Lux,3 Pierre Mowat,3 Aleksandra K Biegun,4 Marc-Jan van Goethem,4 Hynd Remita,5 Sandrine Lacombe2 1Zernike Institute for Advanced Materials, University of Groningen, Gr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Schlathölter T, Eustache P, Porcel E, Salado D, Stefancikova L, Tillement O, Lux F, Mowat P, Biegun AK, van Goethem MJ, Remita H, Lacombe S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Gadolinium based nanoparticles Platinum nanoparticles Protontherapy Nano-sensitization Theranostics Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fa0ef083b22c4654803d02df313a64d5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fa0ef083b22c4654803d02df313a64d5
record_format	dspace
spelling	oai:doaj.org-article:fa0ef083b22c4654803d02df313a64d52021-12-02T00:12:59ZImproving proton therapy by metal-containing nanoparticles: nanoscale insights1178-2013https://doaj.org/article/fa0ef083b22c4654803d02df313a64d52016-04-01T00:00:00Zhttps://www.dovepress.com/improving-proton-therapy-by-metal-containing-nanoparticles-nanoscale-i-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Thomas Schlathölter,1 Pierre Eustache,2 Erika Porcel,2 Daniela Salado,2 Lenka Stefancikova,2 Olivier Tillement,3 Francois Lux,3 Pierre Mowat,3 Aleksandra K Biegun,4 Marc-Jan van Goethem,4 Hynd Remita,5 Sandrine Lacombe2 1Zernike Institute for Advanced Materials, University of Groningen, Groningen, the Netherlands; 2Institut des Sciences Moléculaires d’Orsay (ISMO), Univ. Paris Sud, CNRS, Université Paris Saclay, Orsay Cedex, 3Institut Lumière Matière, Villeurbanne Cedex, France; 4Kernfysisch Versneller Instituut – Center for Advanced Radiation Technology (KVI-CART), University of Groningen, Groningen, the Netherlands; 5Laboratoire de Chimie Physique, Universite Paris-Sud, Orsay Cedex, France Abstract: The use of nanoparticles to enhance the effect of radiation-based cancer treatments is a growing field of study and recently, even nanoparticle-induced improvement of proton therapy performance has been investigated. Aiming at a clinical implementation of this approach, it is essential to characterize the mechanisms underlying the synergistic effects of nanoparticles combined with proton irradiation. In this study, we investigated the effect of platinum- and gadolinium-based nanoparticles on the nanoscale damage induced by a proton beam of therapeutically relevant energy (150 MeV) using plasmid DNA molecular probe. Two conditions of irradiation (0.44 and 3.6 keV/µm) were considered to mimic the beam properties at the entrance and at the end of the proton track. We demonstrate that the two metal-containing nanoparticles amplify, in particular, the induction of nanosize damages (>2 nm) which are most lethal for cells. More importantly, this effect is even more pronounced at the end of the proton track. This work gives a new insight into the underlying mechanisms on the nanoscale and indicates that the addition of metal-based nanoparticles is a promising strategy not only to increase the cell killing action of fast protons, but also to improve tumor targeting. Keywords: gadolinium-based nanoparticles, platinum nanoparticles, nanosensitization, theranosticsSchlathölter TEustache PPorcel ESalado DStefancikova LTillement OLux FMowat PBiegun AKvan Goethem MJRemita HLacombe SDove Medical PressarticleGadolinium based nanoparticlesPlatinum nanoparticlesProtontherapyNano-sensitizationTheranosticsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1549-1556 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gadolinium based nanoparticles Platinum nanoparticles Protontherapy Nano-sensitization Theranostics Medicine (General) R5-920
spellingShingle	Gadolinium based nanoparticles Platinum nanoparticles Protontherapy Nano-sensitization Theranostics Medicine (General) R5-920 Schlathölter T Eustache P Porcel E Salado D Stefancikova L Tillement O Lux F Mowat P Biegun AK van Goethem MJ Remita H Lacombe S Improving proton therapy by metal-containing nanoparticles: nanoscale insights
description	Thomas Schlathölter,1 Pierre Eustache,2 Erika Porcel,2 Daniela Salado,2 Lenka Stefancikova,2 Olivier Tillement,3 Francois Lux,3 Pierre Mowat,3 Aleksandra K Biegun,4 Marc-Jan van Goethem,4 Hynd Remita,5 Sandrine Lacombe2 1Zernike Institute for Advanced Materials, University of Groningen, Groningen, the Netherlands; 2Institut des Sciences Moléculaires d’Orsay (ISMO), Univ. Paris Sud, CNRS, Université Paris Saclay, Orsay Cedex, 3Institut Lumière Matière, Villeurbanne Cedex, France; 4Kernfysisch Versneller Instituut – Center for Advanced Radiation Technology (KVI-CART), University of Groningen, Groningen, the Netherlands; 5Laboratoire de Chimie Physique, Universite Paris-Sud, Orsay Cedex, France Abstract: The use of nanoparticles to enhance the effect of radiation-based cancer treatments is a growing field of study and recently, even nanoparticle-induced improvement of proton therapy performance has been investigated. Aiming at a clinical implementation of this approach, it is essential to characterize the mechanisms underlying the synergistic effects of nanoparticles combined with proton irradiation. In this study, we investigated the effect of platinum- and gadolinium-based nanoparticles on the nanoscale damage induced by a proton beam of therapeutically relevant energy (150 MeV) using plasmid DNA molecular probe. Two conditions of irradiation (0.44 and 3.6 keV/µm) were considered to mimic the beam properties at the entrance and at the end of the proton track. We demonstrate that the two metal-containing nanoparticles amplify, in particular, the induction of nanosize damages (>2 nm) which are most lethal for cells. More importantly, this effect is even more pronounced at the end of the proton track. This work gives a new insight into the underlying mechanisms on the nanoscale and indicates that the addition of metal-based nanoparticles is a promising strategy not only to increase the cell killing action of fast protons, but also to improve tumor targeting. Keywords: gadolinium-based nanoparticles, platinum nanoparticles, nanosensitization, theranostics
format	article
author	Schlathölter T Eustache P Porcel E Salado D Stefancikova L Tillement O Lux F Mowat P Biegun AK van Goethem MJ Remita H Lacombe S
author_facet	Schlathölter T Eustache P Porcel E Salado D Stefancikova L Tillement O Lux F Mowat P Biegun AK van Goethem MJ Remita H Lacombe S
author_sort	Schlathölter T
title	Improving proton therapy by metal-containing nanoparticles: nanoscale insights
title_short	Improving proton therapy by metal-containing nanoparticles: nanoscale insights
title_full	Improving proton therapy by metal-containing nanoparticles: nanoscale insights
title_fullStr	Improving proton therapy by metal-containing nanoparticles: nanoscale insights
title_full_unstemmed	Improving proton therapy by metal-containing nanoparticles: nanoscale insights
title_sort	improving proton therapy by metal-containing nanoparticles: nanoscale insights
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/fa0ef083b22c4654803d02df313a64d5
work_keys_str_mv	AT schlatholtert improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT eustachep improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT porcele improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT saladod improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT stefancikoval improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT tillemento improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT luxf improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT mowatp improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT biegunak improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT vangoethemmj improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT remitah improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights AT lacombes improvingprotontherapybymetalcontainingnanoparticlesnanoscaleinsights
_version_	1718403900476751872

Improving proton therapy by metal-containing nanoparticles: nanoscale insights

Ejemplares similares