Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models

MeCP2 mutations can cause Rett syndrome, a severe childhood neurological disorder. Here the authors show that MeCP2 mediates the higher-order assembly of a large splicing complex Rbfox/LASR, which is disrupted in the mouse models of Rett syndrome.

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Autores principales:	Yan Jiang, Xing Fu, Yuhan Zhang, Shen-Fei Wang, Hong Zhu, Wei-Kang Wang, Lin Zhang, Ping Wu, Catherine C. L. Wong, Jinsong Li, Jinbiao Ma, Ji-Song Guan, Ying Huang, Jingyi Hui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa106e341c1247a4a340882447b44d12
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spelling	oai:doaj.org-article:fa106e341c1247a4a340882447b44d122021-12-02T18:51:22ZRett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models10.1038/s41467-021-26084-32041-1723https://doaj.org/article/fa106e341c1247a4a340882447b44d122021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26084-3https://doaj.org/toc/2041-1723MeCP2 mutations can cause Rett syndrome, a severe childhood neurological disorder. Here the authors show that MeCP2 mediates the higher-order assembly of a large splicing complex Rbfox/LASR, which is disrupted in the mouse models of Rett syndrome.Yan JiangXing FuYuhan ZhangShen-Fei WangHong ZhuWei-Kang WangLin ZhangPing WuCatherine C. L. WongJinsong LiJinbiao MaJi-Song GuanYing HuangJingyi HuiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan Jiang Xing Fu Yuhan Zhang Shen-Fei Wang Hong Zhu Wei-Kang Wang Lin Zhang Ping Wu Catherine C. L. Wong Jinsong Li Jinbiao Ma Ji-Song Guan Ying Huang Jingyi Hui Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models
description	MeCP2 mutations can cause Rett syndrome, a severe childhood neurological disorder. Here the authors show that MeCP2 mediates the higher-order assembly of a large splicing complex Rbfox/LASR, which is disrupted in the mouse models of Rett syndrome.
format	article
author	Yan Jiang Xing Fu Yuhan Zhang Shen-Fei Wang Hong Zhu Wei-Kang Wang Lin Zhang Ping Wu Catherine C. L. Wong Jinsong Li Jinbiao Ma Ji-Song Guan Ying Huang Jingyi Hui
author_facet	Yan Jiang Xing Fu Yuhan Zhang Shen-Fei Wang Hong Zhu Wei-Kang Wang Lin Zhang Ping Wu Catherine C. L. Wong Jinsong Li Jinbiao Ma Ji-Song Guan Ying Huang Jingyi Hui
author_sort	Yan Jiang
title	Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models
title_short	Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models
title_full	Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models
title_fullStr	Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models
title_full_unstemmed	Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models
title_sort	rett syndrome linked to defects in forming the mecp2/rbfox/lasr complex in mouse models
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa106e341c1247a4a340882447b44d12
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Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models

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