Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models

Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models

MeCP2 mutations can cause Rett syndrome, a severe childhood neurological disorder. Here the authors show that MeCP2 mediates the higher-order assembly of a large splicing complex Rbfox/LASR, which is disrupted in the mouse models of Rett syndrome.

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Detalles Bibliográficos
Autores principales: Yan Jiang, Xing Fu, Yuhan Zhang, Shen-Fei Wang, Hong Zhu, Wei-Kang Wang, Lin Zhang, Ping Wu, Catherine C. L. Wong, Jinsong Li, Jinbiao Ma, Ji-Song Guan, Ying Huang, Jingyi Hui
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/fa106e341c1247a4a340882447b44d12
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