HIV-1 tropism determination using a phenotypic Env recombinant viral assay highlights overestimation of CXCR4-usage by genotypic prediction algorithms for CRF01_AE and CRF02_AG [corrected].

HIV-1 tropism determination using a phenotypic Env recombinant viral assay highlights overestimation of CXCR4-usage by genotypic prediction algorithms for CRF01_AE and CRF02_AG [corrected].

<h4>Background</h4>Human Immunodeficiency virus type-1 (HIV) entry into target cells involves binding of the viral envelope (Env) to CD4 and a coreceptor, mainly CCR5 or CXCR4. The only currently licensed HIV entry inhibitor, maraviroc, targets CCR5, and the presence of CXCX4-using strai...

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Autores principales: Martin Mulinge, Morgane Lemaire, Jean-Yves Servais, Arkadiusz Rybicki, Daniel Struck, Eveline Santos da Silva, Chris Verhofstede, Yolanda Lie, Carole Seguin-Devaux, Jean-Claude Schmit, Danielle Perez Bercoff
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fa11ab77848e4cfbb4d04d1cf5e57b17
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