Role of KCNB1 in the prognosis of gliomas and autophagy modulation

Abstract Increasing evidence suggests that ion channel genes play an important role in the progression of gliomas. However, the mechanisms by which ion channel genes influence the progression of glioma are not fully understood. We identified KCNB1 as a novel ion gene, associated with malignant progr...

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Autores principales:	Hao-Yuan Wang, Wen Wang, Yan-Wei Liu, Ming-Yang Li, Ting-Yu Liang, Ji-Ye Li, Hui-Min Hu, Yang Lu, Chen Yao, Yong-Yi Ye, Yong-Zhi Wang, Shi-Zhong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa13a9f16b114b4283361f954ada8437
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spelling	oai:doaj.org-article:fa13a9f16b114b4283361f954ada84372021-12-02T15:06:02ZRole of KCNB1 in the prognosis of gliomas and autophagy modulation10.1038/s41598-017-00045-72045-2322https://doaj.org/article/fa13a9f16b114b4283361f954ada84372017-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00045-7https://doaj.org/toc/2045-2322Abstract Increasing evidence suggests that ion channel genes play an important role in the progression of gliomas. However, the mechanisms by which ion channel genes influence the progression of glioma are not fully understood. We identified KCNB1 as a novel ion gene, associated with malignant progression and favorable overall survival (OS) and progression-free survival (PFS) in glioma patients from three datasets (CGGA, GSE16011 and REMBRANDT). Moreover, we characterized a novel function of autophagy induction accompanied by increased apoptosis and reduced proliferation and invasion of glioma cells for KCNB1. KEGG pathway analysis and in vitro studies suggested that the ERK pathway is involved in KCNB1-mediated regulation of autophagy, which was confirmed by inhibition of KCNB1-induced autophagy by using a selective ERK1/2 inhibitor (U0126) or siERK1/2. In vivo studies showed that KCNB1 induced autophagy while inhibiting tumor growth and increasing survival. Overall, our studies define KCNB1 as a novel prognostic factor for gliomas that exerts its tumor suppressive function through autophagy induction.Hao-Yuan WangWen WangYan-Wei LiuMing-Yang LiTing-Yu LiangJi-Ye LiHui-Min HuYang LuChen YaoYong-Yi YeYong-Zhi WangShi-Zhong ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hao-Yuan Wang Wen Wang Yan-Wei Liu Ming-Yang Li Ting-Yu Liang Ji-Ye Li Hui-Min Hu Yang Lu Chen Yao Yong-Yi Ye Yong-Zhi Wang Shi-Zhong Zhang Role of KCNB1 in the prognosis of gliomas and autophagy modulation
description	Abstract Increasing evidence suggests that ion channel genes play an important role in the progression of gliomas. However, the mechanisms by which ion channel genes influence the progression of glioma are not fully understood. We identified KCNB1 as a novel ion gene, associated with malignant progression and favorable overall survival (OS) and progression-free survival (PFS) in glioma patients from three datasets (CGGA, GSE16011 and REMBRANDT). Moreover, we characterized a novel function of autophagy induction accompanied by increased apoptosis and reduced proliferation and invasion of glioma cells for KCNB1. KEGG pathway analysis and in vitro studies suggested that the ERK pathway is involved in KCNB1-mediated regulation of autophagy, which was confirmed by inhibition of KCNB1-induced autophagy by using a selective ERK1/2 inhibitor (U0126) or siERK1/2. In vivo studies showed that KCNB1 induced autophagy while inhibiting tumor growth and increasing survival. Overall, our studies define KCNB1 as a novel prognostic factor for gliomas that exerts its tumor suppressive function through autophagy induction.
format	article
author	Hao-Yuan Wang Wen Wang Yan-Wei Liu Ming-Yang Li Ting-Yu Liang Ji-Ye Li Hui-Min Hu Yang Lu Chen Yao Yong-Yi Ye Yong-Zhi Wang Shi-Zhong Zhang
author_facet	Hao-Yuan Wang Wen Wang Yan-Wei Liu Ming-Yang Li Ting-Yu Liang Ji-Ye Li Hui-Min Hu Yang Lu Chen Yao Yong-Yi Ye Yong-Zhi Wang Shi-Zhong Zhang
author_sort	Hao-Yuan Wang
title	Role of KCNB1 in the prognosis of gliomas and autophagy modulation
title_short	Role of KCNB1 in the prognosis of gliomas and autophagy modulation
title_full	Role of KCNB1 in the prognosis of gliomas and autophagy modulation
title_fullStr	Role of KCNB1 in the prognosis of gliomas and autophagy modulation
title_full_unstemmed	Role of KCNB1 in the prognosis of gliomas and autophagy modulation
title_sort	role of kcnb1 in the prognosis of gliomas and autophagy modulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fa13a9f16b114b4283361f954ada8437
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Role of KCNB1 in the prognosis of gliomas and autophagy modulation

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