Influence of heart rate correction formulas on QTc interval stability

Abstract Monitoring of QTc interval is mandated in different clinical conditions. Nevertheless, intra-subject variability of QTc intervals reduces the clinical utility of QTc monitoring strategies. Since this variability is partly related to QT heart rate correction, 10 different heart rate correcti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Irena Andršová, Katerina Hnatkova, Martina Šišáková, Ondřej Toman, Peter Smetana, Katharina M. Huster, Petra Barthel, Tomáš Novotný, Georg Schmidt, Marek Malik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa17d2731af747cba93112c959519c09
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fa17d2731af747cba93112c959519c09
record_format	dspace
spelling	oai:doaj.org-article:fa17d2731af747cba93112c959519c092021-12-02T16:14:09ZInfluence of heart rate correction formulas on QTc interval stability10.1038/s41598-021-93774-92045-2322https://doaj.org/article/fa17d2731af747cba93112c959519c092021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93774-9https://doaj.org/toc/2045-2322Abstract Monitoring of QTc interval is mandated in different clinical conditions. Nevertheless, intra-subject variability of QTc intervals reduces the clinical utility of QTc monitoring strategies. Since this variability is partly related to QT heart rate correction, 10 different heart rate corrections (Bazett, Fridericia, Dmitrienko, Framingham, Schlamowitz, Hodges, Ashman, Rautaharju, Sarma, and Rabkin) were applied to 452,440 ECG measurements made in 539 healthy volunteers (259 females, mean age 33.3 ± 8.4 years). For each correction formula, the short term (5-min time-points) and long-term (day-time hours) variability of rate corrected QT values (QTc) was investigated together with the comparisons of the QTc values with individually corrected QTcI values obtained by subject-specific modelling of the QT/RR relationship and hysteresis. The results showed that (a) both in terms of short-term and long-term QTc variability, Bazett correction led to QTc values that were more variable than the results of other corrections (p < 0.00001 for all), (b) the QTc variability by Fridericia and Framingham corrections were not systematically different from each other but were lower than the results of other corrections (p-value between 0.033 and < 0.00001), and (c) on average, Bazett QTc values departed from QTcI intervals more than the QTc values of other corrections. The study concludes that (a) previous suggestions that Bazett correction should no longer be used in clinical practice are fully justified, (b) replacing Bazett correction with Fridericia and/or Framingham corrections would improve clinical QTc monitoring, (c) heart rate stability is needed for valid QTc assessment, and (d) development of further QTc corrections for day-to-day use is not warranted.Irena AndršováKaterina HnatkovaMartina ŠišákováOndřej TomanPeter SmetanaKatharina M. HusterPetra BarthelTomáš NovotnýGeorg SchmidtMarek MalikNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Irena Andršová Katerina Hnatkova Martina Šišáková Ondřej Toman Peter Smetana Katharina M. Huster Petra Barthel Tomáš Novotný Georg Schmidt Marek Malik Influence of heart rate correction formulas on QTc interval stability
description	Abstract Monitoring of QTc interval is mandated in different clinical conditions. Nevertheless, intra-subject variability of QTc intervals reduces the clinical utility of QTc monitoring strategies. Since this variability is partly related to QT heart rate correction, 10 different heart rate corrections (Bazett, Fridericia, Dmitrienko, Framingham, Schlamowitz, Hodges, Ashman, Rautaharju, Sarma, and Rabkin) were applied to 452,440 ECG measurements made in 539 healthy volunteers (259 females, mean age 33.3 ± 8.4 years). For each correction formula, the short term (5-min time-points) and long-term (day-time hours) variability of rate corrected QT values (QTc) was investigated together with the comparisons of the QTc values with individually corrected QTcI values obtained by subject-specific modelling of the QT/RR relationship and hysteresis. The results showed that (a) both in terms of short-term and long-term QTc variability, Bazett correction led to QTc values that were more variable than the results of other corrections (p < 0.00001 for all), (b) the QTc variability by Fridericia and Framingham corrections were not systematically different from each other but were lower than the results of other corrections (p-value between 0.033 and < 0.00001), and (c) on average, Bazett QTc values departed from QTcI intervals more than the QTc values of other corrections. The study concludes that (a) previous suggestions that Bazett correction should no longer be used in clinical practice are fully justified, (b) replacing Bazett correction with Fridericia and/or Framingham corrections would improve clinical QTc monitoring, (c) heart rate stability is needed for valid QTc assessment, and (d) development of further QTc corrections for day-to-day use is not warranted.
format	article
author	Irena Andršová Katerina Hnatkova Martina Šišáková Ondřej Toman Peter Smetana Katharina M. Huster Petra Barthel Tomáš Novotný Georg Schmidt Marek Malik
author_facet	Irena Andršová Katerina Hnatkova Martina Šišáková Ondřej Toman Peter Smetana Katharina M. Huster Petra Barthel Tomáš Novotný Georg Schmidt Marek Malik
author_sort	Irena Andršová
title	Influence of heart rate correction formulas on QTc interval stability
title_short	Influence of heart rate correction formulas on QTc interval stability
title_full	Influence of heart rate correction formulas on QTc interval stability
title_fullStr	Influence of heart rate correction formulas on QTc interval stability
title_full_unstemmed	Influence of heart rate correction formulas on QTc interval stability
title_sort	influence of heart rate correction formulas on qtc interval stability
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa17d2731af747cba93112c959519c09
work_keys_str_mv	AT irenaandrsova influenceofheartratecorrectionformulasonqtcintervalstability AT katerinahnatkova influenceofheartratecorrectionformulasonqtcintervalstability AT martinasisakova influenceofheartratecorrectionformulasonqtcintervalstability AT ondrejtoman influenceofheartratecorrectionformulasonqtcintervalstability AT petersmetana influenceofheartratecorrectionformulasonqtcintervalstability AT katharinamhuster influenceofheartratecorrectionformulasonqtcintervalstability AT petrabarthel influenceofheartratecorrectionformulasonqtcintervalstability AT tomasnovotny influenceofheartratecorrectionformulasonqtcintervalstability AT georgschmidt influenceofheartratecorrectionformulasonqtcintervalstability AT marekmalik influenceofheartratecorrectionformulasonqtcintervalstability
_version_	1718384388668915712

Influence of heart rate correction formulas on QTc interval stability

Ejemplares similares