Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.

<h4>Aims</h4>We aimed to assess the effects of psyllium supplementation on insulin sensitivity and other parameters of the metabolic syndrome in an at risk adolescent population.<h4>Methods</h4>This study encompassed a participant-blinded, randomized, placebo-controlled, cros...

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Autores principales:	Martin de Bock, José G B Derraik, Christine M Brennan, Janene B Biggs, Greg C Smith, David Cameron-Smith, Clare R Wall, Wayne S Cutfield
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa18bc02fc364b8ebb5493648b106d9a
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spelling	oai:doaj.org-article:fa18bc02fc364b8ebb5493648b106d9a2021-11-18T07:10:41ZPsyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.1932-620310.1371/journal.pone.0041735https://doaj.org/article/fa18bc02fc364b8ebb5493648b106d9a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22848584/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aims</h4>We aimed to assess the effects of psyllium supplementation on insulin sensitivity and other parameters of the metabolic syndrome in an at risk adolescent population.<h4>Methods</h4>This study encompassed a participant-blinded, randomized, placebo-controlled, crossover trial. Subjects were 47 healthy adolescent males aged 15-16 years, recruited from secondary schools in lower socio-economic areas with high rates of obesity. Participants received 6 g/day of psyllium or placebo for 6 weeks, with a two-week washout before crossing over. Fasting lipid profiles, ambulatory blood pressure, auxological data, body composition, activity levels, and three-day food records were collected at baseline and after each 6-week intervention. Insulin sensitivity was measured by the Matsuda method using glucose and insulin values from an oral glucose tolerance test.<h4>Results</h4>45 subjects completed the study, and compliance was very high: 87% of participants took >80% of prescribed capsules. At baseline, 44% of subjects were overweight or obese. 28% had decreased insulin sensitivity, but none had impaired glucose tolerance. Fibre supplementation led to a 4% reduction in android fat to gynoid fat ratio (p = 0.019), as well as a 0.12 mmol/l (6%) reduction in LDL cholesterol (p = 0.042). No associated adverse events were recorded.<h4>Conclusions</h4>Dietary supplementation with 6 g/day of psyllium over 6 weeks improves fat distribution and lipid profile (parameters of the metabolic syndrome) in an at risk population of adolescent males.<h4>Trial registration</h4>Australian New Zealand Clinical Trials Registry ACTRN12609000888268.Martin de BockJosé G B DerraikChristine M BrennanJanene B BiggsGreg C SmithDavid Cameron-SmithClare R WallWayne S CutfieldPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e41735 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin de Bock José G B Derraik Christine M Brennan Janene B Biggs Greg C Smith David Cameron-Smith Clare R Wall Wayne S Cutfield Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.
description	<h4>Aims</h4>We aimed to assess the effects of psyllium supplementation on insulin sensitivity and other parameters of the metabolic syndrome in an at risk adolescent population.<h4>Methods</h4>This study encompassed a participant-blinded, randomized, placebo-controlled, crossover trial. Subjects were 47 healthy adolescent males aged 15-16 years, recruited from secondary schools in lower socio-economic areas with high rates of obesity. Participants received 6 g/day of psyllium or placebo for 6 weeks, with a two-week washout before crossing over. Fasting lipid profiles, ambulatory blood pressure, auxological data, body composition, activity levels, and three-day food records were collected at baseline and after each 6-week intervention. Insulin sensitivity was measured by the Matsuda method using glucose and insulin values from an oral glucose tolerance test.<h4>Results</h4>45 subjects completed the study, and compliance was very high: 87% of participants took >80% of prescribed capsules. At baseline, 44% of subjects were overweight or obese. 28% had decreased insulin sensitivity, but none had impaired glucose tolerance. Fibre supplementation led to a 4% reduction in android fat to gynoid fat ratio (p = 0.019), as well as a 0.12 mmol/l (6%) reduction in LDL cholesterol (p = 0.042). No associated adverse events were recorded.<h4>Conclusions</h4>Dietary supplementation with 6 g/day of psyllium over 6 weeks improves fat distribution and lipid profile (parameters of the metabolic syndrome) in an at risk population of adolescent males.<h4>Trial registration</h4>Australian New Zealand Clinical Trials Registry ACTRN12609000888268.
format	article
author	Martin de Bock José G B Derraik Christine M Brennan Janene B Biggs Greg C Smith David Cameron-Smith Clare R Wall Wayne S Cutfield
author_facet	Martin de Bock José G B Derraik Christine M Brennan Janene B Biggs Greg C Smith David Cameron-Smith Clare R Wall Wayne S Cutfield
author_sort	Martin de Bock
title	Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.
title_short	Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.
title_full	Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.
title_fullStr	Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.
title_full_unstemmed	Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.
title_sort	psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fa18bc02fc364b8ebb5493648b106d9a
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Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial.

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