Multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.

We aimed to compare the volumetric-modulated arc therapy (VMAT) plans with or without multi-criteria optimization (MCO) on commercial treatment-planning systems (Eclipse, Varian Medical System, Palo Alto, CA, USA) for patients with prostate cancer. We selected 25 plans of patients with prostate canc...

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Autores principales:	Jongmoo Park, Jaehyeon Park, Sean Oh, Ji Woon Yea, Jeong Eun Lee, Jae Won Park
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa1ae9637b864166aef8baae6a7dab00
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spelling	oai:doaj.org-article:fa1ae9637b864166aef8baae6a7dab002021-12-02T20:14:41ZMulti-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.1932-620310.1371/journal.pone.0257216https://doaj.org/article/fa1ae9637b864166aef8baae6a7dab002021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257216https://doaj.org/toc/1932-6203We aimed to compare the volumetric-modulated arc therapy (VMAT) plans with or without multi-criteria optimization (MCO) on commercial treatment-planning systems (Eclipse, Varian Medical System, Palo Alto, CA, USA) for patients with prostate cancer. We selected 25 plans of patients with prostate cancer who were previously treated on the basis of a VMAT plan. All plans were imported into the Eclipse Treatment Planning System version 15.6, and re-calculation and re-optimization were performed. The MCO plan was then generated. The dosimetric quality of the plans was evaluated using dosimetric parameters and dose indices that account for target coverage and sparing of the organs at risk (OARs). We defined the rectum, bladder, and bilateral femoral heads. The VMAT-MCO plan offers an improvement of gross treatment volume coverage with increased minimal dose and reduced maximal dose. In the planning treatment volume, the Dmean and better gradient, homogeneity, and conformity indexes improved despite the increasing hot and cold spots. When implemented through the MCO plan, a steeper fall off the adjacent OARs in the overlap area was achieved to obtain lower dose parameters. MCO generated better sparing of the rectum and bladder through a tradeoff of the increasing dose to the bilateral femoral heads within the tolerable dose constraints. Compared with re-optimization and re-calculation, respectively, significant dose reductions were observed in the bladder (241 cGy and 254 cGy; p<0.001) and rectum (474 cGy and 604 cGy, p<0.001) with the MCO. Planning evaluation and dosimetric measurements showed that the VMAT-MCO plan using visualized navigation can provide sparing of OAR doses without compromising the target coverage in the same OAR dose constraints.Jongmoo ParkJaehyeon ParkSean OhJi Woon YeaJeong Eun LeeJae Won ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257216 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jongmoo Park Jaehyeon Park Sean Oh Ji Woon Yea Jeong Eun Lee Jae Won Park Multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.
description	We aimed to compare the volumetric-modulated arc therapy (VMAT) plans with or without multi-criteria optimization (MCO) on commercial treatment-planning systems (Eclipse, Varian Medical System, Palo Alto, CA, USA) for patients with prostate cancer. We selected 25 plans of patients with prostate cancer who were previously treated on the basis of a VMAT plan. All plans were imported into the Eclipse Treatment Planning System version 15.6, and re-calculation and re-optimization were performed. The MCO plan was then generated. The dosimetric quality of the plans was evaluated using dosimetric parameters and dose indices that account for target coverage and sparing of the organs at risk (OARs). We defined the rectum, bladder, and bilateral femoral heads. The VMAT-MCO plan offers an improvement of gross treatment volume coverage with increased minimal dose and reduced maximal dose. In the planning treatment volume, the Dmean and better gradient, homogeneity, and conformity indexes improved despite the increasing hot and cold spots. When implemented through the MCO plan, a steeper fall off the adjacent OARs in the overlap area was achieved to obtain lower dose parameters. MCO generated better sparing of the rectum and bladder through a tradeoff of the increasing dose to the bilateral femoral heads within the tolerable dose constraints. Compared with re-optimization and re-calculation, respectively, significant dose reductions were observed in the bladder (241 cGy and 254 cGy; p<0.001) and rectum (474 cGy and 604 cGy, p<0.001) with the MCO. Planning evaluation and dosimetric measurements showed that the VMAT-MCO plan using visualized navigation can provide sparing of OAR doses without compromising the target coverage in the same OAR dose constraints.
format	article
author	Jongmoo Park Jaehyeon Park Sean Oh Ji Woon Yea Jeong Eun Lee Jae Won Park
author_facet	Jongmoo Park Jaehyeon Park Sean Oh Ji Woon Yea Jeong Eun Lee Jae Won Park
author_sort	Jongmoo Park
title	Multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.
title_short	Multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.
title_full	Multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.
title_fullStr	Multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.
title_full_unstemmed	Multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.
title_sort	multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fa1ae9637b864166aef8baae6a7dab00
work_keys_str_mv	AT jongmoopark multicriteriaoptimizationforplanningvolumetricmodulatedarctherapyforprostatecancer AT jaehyeonpark multicriteriaoptimizationforplanningvolumetricmodulatedarctherapyforprostatecancer AT seanoh multicriteriaoptimizationforplanningvolumetricmodulatedarctherapyforprostatecancer AT jiwoonyea multicriteriaoptimizationforplanningvolumetricmodulatedarctherapyforprostatecancer AT jeongeunlee multicriteriaoptimizationforplanningvolumetricmodulatedarctherapyforprostatecancer AT jaewonpark multicriteriaoptimizationforplanningvolumetricmodulatedarctherapyforprostatecancer
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Multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer.

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