Paternal age in relation to offspring intelligence in the West of Scotland Twenty-07 prospective cohort study.

<h4>Background</h4>The adverse effects of advancing maternal age on offspring's health and development are well understood. Much less is known about the impact of paternal age.<h4>Methods</h4>We explored paternal age-offspring cognition associations in 772 participants f...

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Autores principales:	Elise Whitley, Ian J Deary, Geoff Der, G David Batty, Michaela Benzeval
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa1dd373c6904a35a759d73ebe2a80b7
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spelling	oai:doaj.org-article:fa1dd373c6904a35a759d73ebe2a80b72021-11-18T08:05:09ZPaternal age in relation to offspring intelligence in the West of Scotland Twenty-07 prospective cohort study.1932-620310.1371/journal.pone.0052112https://doaj.org/article/fa1dd373c6904a35a759d73ebe2a80b72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272219/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The adverse effects of advancing maternal age on offspring's health and development are well understood. Much less is known about the impact of paternal age.<h4>Methods</h4>We explored paternal age-offspring cognition associations in 772 participants from the West of Scotland Twenty-07 study. Offspring cognitive ability was assessed using Part 1 of the Alice Heim 4 (AH4) test of General Intelligence and by reaction time (RT).<h4>Results</h4>There was no evidence of a parental age association with offspring RT. However, we observed an inverse U-shaped association between paternal age and offspring AH4 score with the lowest scores observed for the youngest and oldest fathers. Adjustment for parental education and socioeconomic status somewhat attenuated this association. Adjustment for number of, particularly older, siblings further reduced the scores of children of younger fathers and appeared to account for the lower offspring scores in the oldest paternal age group.<h4>Conclusion</h4>We observed a paternal age association with AH4 but not RT, a measure of cognition largely independent of social and educational experiences. Factors such as parental education, socioeconomic status and number of, particularly older, siblings may play an important role in accounting for paternal age-AH4 associations. Future studies should include parental intelligence.Elise WhitleyIan J DearyGeoff DerG David BattyMichaela BenzevalPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52112 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elise Whitley Ian J Deary Geoff Der G David Batty Michaela Benzeval Paternal age in relation to offspring intelligence in the West of Scotland Twenty-07 prospective cohort study.
description	<h4>Background</h4>The adverse effects of advancing maternal age on offspring's health and development are well understood. Much less is known about the impact of paternal age.<h4>Methods</h4>We explored paternal age-offspring cognition associations in 772 participants from the West of Scotland Twenty-07 study. Offspring cognitive ability was assessed using Part 1 of the Alice Heim 4 (AH4) test of General Intelligence and by reaction time (RT).<h4>Results</h4>There was no evidence of a parental age association with offspring RT. However, we observed an inverse U-shaped association between paternal age and offspring AH4 score with the lowest scores observed for the youngest and oldest fathers. Adjustment for parental education and socioeconomic status somewhat attenuated this association. Adjustment for number of, particularly older, siblings further reduced the scores of children of younger fathers and appeared to account for the lower offspring scores in the oldest paternal age group.<h4>Conclusion</h4>We observed a paternal age association with AH4 but not RT, a measure of cognition largely independent of social and educational experiences. Factors such as parental education, socioeconomic status and number of, particularly older, siblings may play an important role in accounting for paternal age-AH4 associations. Future studies should include parental intelligence.
format	article
author	Elise Whitley Ian J Deary Geoff Der G David Batty Michaela Benzeval
author_facet	Elise Whitley Ian J Deary Geoff Der G David Batty Michaela Benzeval
author_sort	Elise Whitley
title	Paternal age in relation to offspring intelligence in the West of Scotland Twenty-07 prospective cohort study.
title_short	Paternal age in relation to offspring intelligence in the West of Scotland Twenty-07 prospective cohort study.
title_full	Paternal age in relation to offspring intelligence in the West of Scotland Twenty-07 prospective cohort study.
title_fullStr	Paternal age in relation to offspring intelligence in the West of Scotland Twenty-07 prospective cohort study.
title_full_unstemmed	Paternal age in relation to offspring intelligence in the West of Scotland Twenty-07 prospective cohort study.
title_sort	paternal age in relation to offspring intelligence in the west of scotland twenty-07 prospective cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/fa1dd373c6904a35a759d73ebe2a80b7
work_keys_str_mv	AT elisewhitley paternalageinrelationtooffspringintelligenceinthewestofscotlandtwenty07prospectivecohortstudy AT ianjdeary paternalageinrelationtooffspringintelligenceinthewestofscotlandtwenty07prospectivecohortstudy AT geoffder paternalageinrelationtooffspringintelligenceinthewestofscotlandtwenty07prospectivecohortstudy AT gdavidbatty paternalageinrelationtooffspringintelligenceinthewestofscotlandtwenty07prospectivecohortstudy AT michaelabenzeval paternalageinrelationtooffspringintelligenceinthewestofscotlandtwenty07prospectivecohortstudy
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Paternal age in relation to offspring intelligence in the West of Scotland Twenty-07 prospective cohort study.

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