Mitochondria in Diabetic Kidney Disease

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple signaling pathways with merging outcomes including thickening of the basement membrane, podocyte loss, mesangial expansion, t...

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Autores principales:	Amna Ayesha Ahmad, Shayna Odeal Draves, Mariana Rosca
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes diabetic kidney disease mitochondria bioenergetics redox status Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/fa1ef0bc8b8341198e53cc208d328531
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spelling	oai:doaj.org-article:fa1ef0bc8b8341198e53cc208d3285312021-11-25T17:09:34ZMitochondria in Diabetic Kidney Disease10.3390/cells101129452073-4409https://doaj.org/article/fa1ef0bc8b8341198e53cc208d3285312021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2945https://doaj.org/toc/2073-4409Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple signaling pathways with merging outcomes including thickening of the basement membrane, podocyte loss, mesangial expansion, tubular atrophy, and interstitial inflammation and fibrosis. The glomerulo-tubular balance and tubule-glomerular feedback support an increased glomerular filtration and tubular reabsorption, with the latter relying heavily on ATP and increasing the energy demand. There is evidence that alterations in mitochondrial bioenergetics in kidney cells lead to these pathologic changes and contribute to the progression of DKD towards ESRD. This review will focus on the dialogue between alterations in bioenergetics in glomerular and tubular cells and its role in the development of DKD. Alterations in energy substrate selection, electron transport chain, ATP generation, oxidative stress, redox status, protein posttranslational modifications, mitochondrial dynamics, and quality control will be discussed. Understanding the role of bioenergetics in the progression of diabetic DKD may provide novel therapeutic approaches to delay its progression to ESRD.Amna Ayesha AhmadShayna Odeal DravesMariana RoscaMDPI AGarticlediabetesdiabetic kidney diseasemitochondriabioenergeticsredox statusBiology (General)QH301-705.5ENCells, Vol 10, Iss 2945, p 2945 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes diabetic kidney disease mitochondria bioenergetics redox status Biology (General) QH301-705.5
spellingShingle	diabetes diabetic kidney disease mitochondria bioenergetics redox status Biology (General) QH301-705.5 Amna Ayesha Ahmad Shayna Odeal Draves Mariana Rosca Mitochondria in Diabetic Kidney Disease
description	Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD) in the USA. The pathogenesis of DKD is multifactorial and involves activation of multiple signaling pathways with merging outcomes including thickening of the basement membrane, podocyte loss, mesangial expansion, tubular atrophy, and interstitial inflammation and fibrosis. The glomerulo-tubular balance and tubule-glomerular feedback support an increased glomerular filtration and tubular reabsorption, with the latter relying heavily on ATP and increasing the energy demand. There is evidence that alterations in mitochondrial bioenergetics in kidney cells lead to these pathologic changes and contribute to the progression of DKD towards ESRD. This review will focus on the dialogue between alterations in bioenergetics in glomerular and tubular cells and its role in the development of DKD. Alterations in energy substrate selection, electron transport chain, ATP generation, oxidative stress, redox status, protein posttranslational modifications, mitochondrial dynamics, and quality control will be discussed. Understanding the role of bioenergetics in the progression of diabetic DKD may provide novel therapeutic approaches to delay its progression to ESRD.
format	article
author	Amna Ayesha Ahmad Shayna Odeal Draves Mariana Rosca
author_facet	Amna Ayesha Ahmad Shayna Odeal Draves Mariana Rosca
author_sort	Amna Ayesha Ahmad
title	Mitochondria in Diabetic Kidney Disease
title_short	Mitochondria in Diabetic Kidney Disease
title_full	Mitochondria in Diabetic Kidney Disease
title_fullStr	Mitochondria in Diabetic Kidney Disease
title_full_unstemmed	Mitochondria in Diabetic Kidney Disease
title_sort	mitochondria in diabetic kidney disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fa1ef0bc8b8341198e53cc208d328531
work_keys_str_mv	AT amnaayeshaahmad mitochondriaindiabetickidneydisease AT shaynaodealdraves mitochondriaindiabetickidneydisease AT marianarosca mitochondriaindiabetickidneydisease
_version_	1718412690027708416

Mitochondria in Diabetic Kidney Disease

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