Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy

Asieh Hosseini1, Mohammad Sharifzadeh1, Seyed Mahdi Rezayat2, Gholamreza Hassanzadeh3, Shokoufeh Hassani1, Maryam Baeeri1, Vahid Shetab-Bushehri4, Dmitry A Kuznetsov5, Mohammad Abdollahi11Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran,...

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Autores principales:	Asieh Hosseini, Mohammad Sharifzadeh, Seyed Mahdi Rezayat, et al
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Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fa1f9fd9124047988e1e47449ca019ee
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spelling	oai:doaj.org-article:fa1f9fd9124047988e1e47449ca019ee2021-12-02T00:30:59ZBenefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy1176-91141178-2013https://doaj.org/article/fa1f9fd9124047988e1e47449ca019ee2010-07-01T00:00:00Zhttp://www.dovepress.com/benefit-of-magnesium-25-carrying-porphyrin-fullerene-nanoparticles-in--a4866https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Asieh Hosseini1, Mohammad Sharifzadeh1, Seyed Mahdi Rezayat2, Gholamreza Hassanzadeh3, Shokoufeh Hassani1, Maryam Baeeri1, Vahid Shetab-Bushehri4, Dmitry A Kuznetsov5, Mohammad Abdollahi11Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran; 2Faculty of Advanced Science and Technology in Medicine, Tehran University of Medical Sciences and Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran; 3Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 4Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; 5Department of Medicinal Nanobiotechnologies, N. I. Pirogoff Russian State Medical University, Moscow, Russian FederationAbstract: Diabetic neuropathy (DN) is a debilitating disorder occurring in most diabetic patients without a viable treatment yet. The present work examined the protective effect of 25Mg-PMC16 nanoparticle (porphyrin adducts of cyclohexil fullerene-C60) in a rat model of streptozotocin (STZ)-induced DN. 25Mg-PMC16 (0.5 lethal dose50 [LD50]) was administered intravenously in two consecutive days before intraperitoneal injection of STZ (45 mg/kg). 24Mg-PMC16 and MgCl2 were used as controls. Blood 2,3-diphosphoglycerate (2,3-DPG), oxidative stress biomarkers, adenosine triphosphate (ATP) level in dorsal root ganglion (DRG) neurons were determined as biomarkers of DN. Results indicated that 2,3-DPG and ATP decreased whereas oxidative stress increased by induction of DN which all were improved in 25Mg-PMC16-treated animals. No significant changes were observed by administration of 24Mg-PMC16 or MgCl2 in DN rats. It is concluded that in DN, oxidative stress initiates injuries to DRG neurons that finally results in death of neurons whereas administration of 25Mg-PMC16 by release of Mg and increasing ATP acts protectively.Keywords: diabetes, neuropathy, 25Mg-magnetic isotope effect, porphyrin-fullerene nanoparticles, oxidative stress, adenosine triphosphate, nanotechnology Asieh HosseiniMohammad SharifzadehSeyed Mahdi Rezayatet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 517-523 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Asieh Hosseini Mohammad Sharifzadeh Seyed Mahdi Rezayat et al Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
description	Asieh Hosseini1, Mohammad Sharifzadeh1, Seyed Mahdi Rezayat2, Gholamreza Hassanzadeh3, Shokoufeh Hassani1, Maryam Baeeri1, Vahid Shetab-Bushehri4, Dmitry A Kuznetsov5, Mohammad Abdollahi11Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran; 2Faculty of Advanced Science and Technology in Medicine, Tehran University of Medical Sciences and Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran; 3Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 4Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; 5Department of Medicinal Nanobiotechnologies, N. I. Pirogoff Russian State Medical University, Moscow, Russian FederationAbstract: Diabetic neuropathy (DN) is a debilitating disorder occurring in most diabetic patients without a viable treatment yet. The present work examined the protective effect of 25Mg-PMC16 nanoparticle (porphyrin adducts of cyclohexil fullerene-C60) in a rat model of streptozotocin (STZ)-induced DN. 25Mg-PMC16 (0.5 lethal dose50 [LD50]) was administered intravenously in two consecutive days before intraperitoneal injection of STZ (45 mg/kg). 24Mg-PMC16 and MgCl2 were used as controls. Blood 2,3-diphosphoglycerate (2,3-DPG), oxidative stress biomarkers, adenosine triphosphate (ATP) level in dorsal root ganglion (DRG) neurons were determined as biomarkers of DN. Results indicated that 2,3-DPG and ATP decreased whereas oxidative stress increased by induction of DN which all were improved in 25Mg-PMC16-treated animals. No significant changes were observed by administration of 24Mg-PMC16 or MgCl2 in DN rats. It is concluded that in DN, oxidative stress initiates injuries to DRG neurons that finally results in death of neurons whereas administration of 25Mg-PMC16 by release of Mg and increasing ATP acts protectively.Keywords: diabetes, neuropathy, 25Mg-magnetic isotope effect, porphyrin-fullerene nanoparticles, oxidative stress, adenosine triphosphate, nanotechnology
format	article
author	Asieh Hosseini Mohammad Sharifzadeh Seyed Mahdi Rezayat et al
author_facet	Asieh Hosseini Mohammad Sharifzadeh Seyed Mahdi Rezayat et al
author_sort	Asieh Hosseini
title	Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
title_short	Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
title_full	Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
title_fullStr	Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
title_full_unstemmed	Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
title_sort	benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/fa1f9fd9124047988e1e47449ca019ee
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Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy

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