Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis

Drug resistant tuberculosis (TB) infections are emerging at a high rate, with only few therapeutic options currently available. Here, the authors report synthetic analogues of the natural product sansanmycin that target mycobacterial cell wall biosynthesis and represent potent leads for improved ant...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anh T. Tran, Emma E. Watson, Venugopal Pujari, Trent Conroy, Luke J. Dowman, Andrew M. Giltrap, Angel Pang, Weng Ruh Wong, Roger G. Linington, Sebabrata Mahapatra, Jessica Saunders, Susan A. Charman, Nicholas P. West, Timothy D. H. Bugg, Julie Tod, Christopher G. Dowson, David I. Roper, Dean C. Crick, Warwick J. Britton, Richard J. Payne
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa20939585404c08a152992a15e9084c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fa20939585404c08a152992a15e9084c
record_format	dspace
spelling	oai:doaj.org-article:fa20939585404c08a152992a15e9084c2021-12-02T15:39:02ZSansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis10.1038/ncomms144142041-1723https://doaj.org/article/fa20939585404c08a152992a15e9084c2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14414https://doaj.org/toc/2041-1723Drug resistant tuberculosis (TB) infections are emerging at a high rate, with only few therapeutic options currently available. Here, the authors report synthetic analogues of the natural product sansanmycin that target mycobacterial cell wall biosynthesis and represent potent leads for improved anti-TB treatments.Anh T. TranEmma E. WatsonVenugopal PujariTrent ConroyLuke J. DowmanAndrew M. GiltrapAngel PangWeng Ruh WongRoger G. LiningtonSebabrata MahapatraJessica SaundersSusan A. CharmanNicholas P. WestTimothy D. H. BuggJulie TodChristopher G. DowsonDavid I. RoperDean C. CrickWarwick J. BrittonRichard J. PayneNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anh T. Tran Emma E. Watson Venugopal Pujari Trent Conroy Luke J. Dowman Andrew M. Giltrap Angel Pang Weng Ruh Wong Roger G. Linington Sebabrata Mahapatra Jessica Saunders Susan A. Charman Nicholas P. West Timothy D. H. Bugg Julie Tod Christopher G. Dowson David I. Roper Dean C. Crick Warwick J. Britton Richard J. Payne Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis
description	Drug resistant tuberculosis (TB) infections are emerging at a high rate, with only few therapeutic options currently available. Here, the authors report synthetic analogues of the natural product sansanmycin that target mycobacterial cell wall biosynthesis and represent potent leads for improved anti-TB treatments.
format	article
author	Anh T. Tran Emma E. Watson Venugopal Pujari Trent Conroy Luke J. Dowman Andrew M. Giltrap Angel Pang Weng Ruh Wong Roger G. Linington Sebabrata Mahapatra Jessica Saunders Susan A. Charman Nicholas P. West Timothy D. H. Bugg Julie Tod Christopher G. Dowson David I. Roper Dean C. Crick Warwick J. Britton Richard J. Payne
author_facet	Anh T. Tran Emma E. Watson Venugopal Pujari Trent Conroy Luke J. Dowman Andrew M. Giltrap Angel Pang Weng Ruh Wong Roger G. Linington Sebabrata Mahapatra Jessica Saunders Susan A. Charman Nicholas P. West Timothy D. H. Bugg Julie Tod Christopher G. Dowson David I. Roper Dean C. Crick Warwick J. Britton Richard J. Payne
author_sort	Anh T. Tran
title	Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis
title_short	Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis
title_full	Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis
title_fullStr	Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis
title_full_unstemmed	Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis
title_sort	sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid i biosynthesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fa20939585404c08a152992a15e9084c
work_keys_str_mv	AT anhttran sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT emmaewatson sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT venugopalpujari sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT trentconroy sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT lukejdowman sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT andrewmgiltrap sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT angelpang sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT wengruhwong sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT rogerglinington sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT sebabratamahapatra sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT jessicasaunders sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT susanacharman sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT nicholaspwest sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT timothydhbugg sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT julietod sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT christophergdowson sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT davidiroper sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT deanccrick sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT warwickjbritton sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis AT richardjpayne sansanmycinnaturalproductanaloguesaspotentandselectiveantimycobacterialsthatinhibitlipidibiosynthesis
_version_	1718386028725665792

Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis

Ejemplares similares