PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
The primary cilium is required for the autophagic response to shear stress. Here, the authors show that PI3KC2α has a role in ciliogenesis and promotes local PI3P production upon shear stress to induce autophagy that is distinct from VPS34-driven starvation-induced autophagy.
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2020
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oai:doaj.org-article:fa222810d04142ff9c1ee0a2e1dc9f962021-12-02T17:31:09ZPI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress10.1038/s41467-019-14086-12041-1723https://doaj.org/article/fa222810d04142ff9c1ee0a2e1dc9f962020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14086-1https://doaj.org/toc/2041-1723The primary cilium is required for the autophagic response to shear stress. Here, the authors show that PI3KC2α has a role in ciliogenesis and promotes local PI3P production upon shear stress to induce autophagy that is distinct from VPS34-driven starvation-induced autophagy.Asma BoukhalfaAnna Chiara NascimbeniDamien RamelNicolas DupontEmilio HirschStephanie GayralMuriel LaffarguePatrice CodognoEtienne MorelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
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Science Q Asma Boukhalfa Anna Chiara Nascimbeni Damien Ramel Nicolas Dupont Emilio Hirsch Stephanie Gayral Muriel Laffargue Patrice Codogno Etienne Morel PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress |
description |
The primary cilium is required for the autophagic response to shear stress. Here, the authors show that PI3KC2α has a role in ciliogenesis and promotes local PI3P production upon shear stress to induce autophagy that is distinct from VPS34-driven starvation-induced autophagy. |
format |
article |
author |
Asma Boukhalfa Anna Chiara Nascimbeni Damien Ramel Nicolas Dupont Emilio Hirsch Stephanie Gayral Muriel Laffargue Patrice Codogno Etienne Morel |
author_facet |
Asma Boukhalfa Anna Chiara Nascimbeni Damien Ramel Nicolas Dupont Emilio Hirsch Stephanie Gayral Muriel Laffargue Patrice Codogno Etienne Morel |
author_sort |
Asma Boukhalfa |
title |
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress |
title_short |
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress |
title_full |
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress |
title_fullStr |
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress |
title_full_unstemmed |
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress |
title_sort |
pi3kc2α-dependent and vps34-independent generation of pi3p controls primary cilium-mediated autophagy in response to shear stress |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/fa222810d04142ff9c1ee0a2e1dc9f96 |
work_keys_str_mv |
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