Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Here, Bachmann et al. provide data on long-term dynamics of the HIV-1 reservoir in 1,057 individuals on suppressive antiretroviral therapy and show that in 26.6% of individuals the reservoir increases. Viral blips and low-level viremia are significantly associated with a slower reservoir decay.

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Autores principales:	Nadine Bachmann, Chantal von Siebenthal, Valentina Vongrad, Teja Turk, Kathrin Neumann, Niko Beerenwinkel, Jasmina Bogojeska, Jaques Fellay, Volker Roth, Yik Lim Kok, Christian W. Thorball, Alessandro Borghesi, Sonali Parbhoo, Mario Wieser, Jürg Böni, Matthieu Perreau, Thomas Klimkait, Sabine Yerly, Manuel Battegay, Andri Rauch, Matthias Hoffmann, Enos Bernasconi, Matthias Cavassini, Roger D. Kouyos, Huldrych F. Günthard, Karin J. Metzner, the Swiss HIV Cohort Study
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa247e2145d04121aef2b955046ada25
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spelling	oai:doaj.org-article:fa247e2145d04121aef2b955046ada252021-12-02T16:57:09ZDeterminants of HIV-1 reservoir size and long-term dynamics during suppressive ART10.1038/s41467-019-10884-92041-1723https://doaj.org/article/fa247e2145d04121aef2b955046ada252019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10884-9https://doaj.org/toc/2041-1723Here, Bachmann et al. provide data on long-term dynamics of the HIV-1 reservoir in 1,057 individuals on suppressive antiretroviral therapy and show that in 26.6% of individuals the reservoir increases. Viral blips and low-level viremia are significantly associated with a slower reservoir decay.Nadine BachmannChantal von SiebenthalValentina VongradTeja TurkKathrin NeumannNiko BeerenwinkelJasmina BogojeskaJaques FellayVolker RothYik Lim KokChristian W. ThorballAlessandro BorghesiSonali ParbhooMario WieserJürg BöniMatthieu PerreauThomas KlimkaitSabine YerlyManuel BattegayAndri RauchMatthias HoffmannEnos BernasconiMatthias CavassiniRoger D. KouyosHuldrych F. GünthardKarin J. Metznerthe Swiss HIV Cohort StudyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadine Bachmann Chantal von Siebenthal Valentina Vongrad Teja Turk Kathrin Neumann Niko Beerenwinkel Jasmina Bogojeska Jaques Fellay Volker Roth Yik Lim Kok Christian W. Thorball Alessandro Borghesi Sonali Parbhoo Mario Wieser Jürg Böni Matthieu Perreau Thomas Klimkait Sabine Yerly Manuel Battegay Andri Rauch Matthias Hoffmann Enos Bernasconi Matthias Cavassini Roger D. Kouyos Huldrych F. Günthard Karin J. Metzner the Swiss HIV Cohort Study Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
description	Here, Bachmann et al. provide data on long-term dynamics of the HIV-1 reservoir in 1,057 individuals on suppressive antiretroviral therapy and show that in 26.6% of individuals the reservoir increases. Viral blips and low-level viremia are significantly associated with a slower reservoir decay.
format	article
author	Nadine Bachmann Chantal von Siebenthal Valentina Vongrad Teja Turk Kathrin Neumann Niko Beerenwinkel Jasmina Bogojeska Jaques Fellay Volker Roth Yik Lim Kok Christian W. Thorball Alessandro Borghesi Sonali Parbhoo Mario Wieser Jürg Böni Matthieu Perreau Thomas Klimkait Sabine Yerly Manuel Battegay Andri Rauch Matthias Hoffmann Enos Bernasconi Matthias Cavassini Roger D. Kouyos Huldrych F. Günthard Karin J. Metzner the Swiss HIV Cohort Study
author_facet	Nadine Bachmann Chantal von Siebenthal Valentina Vongrad Teja Turk Kathrin Neumann Niko Beerenwinkel Jasmina Bogojeska Jaques Fellay Volker Roth Yik Lim Kok Christian W. Thorball Alessandro Borghesi Sonali Parbhoo Mario Wieser Jürg Böni Matthieu Perreau Thomas Klimkait Sabine Yerly Manuel Battegay Andri Rauch Matthias Hoffmann Enos Bernasconi Matthias Cavassini Roger D. Kouyos Huldrych F. Günthard Karin J. Metzner the Swiss HIV Cohort Study
author_sort	Nadine Bachmann
title	Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
title_short	Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
title_full	Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
title_fullStr	Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
title_full_unstemmed	Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART
title_sort	determinants of hiv-1 reservoir size and long-term dynamics during suppressive art
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fa247e2145d04121aef2b955046ada25
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Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

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