Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population

Abstract This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based o...

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Autores principales:	Tian-Jong Chang, Cai-Mei Zheng, Mei-Yi Wu, Tzu-Ting Chen, Yun-Chun Wu, Yi-Lien Wu, Hsin-Ting Lin, Jing-Quan Zheng, Nain-Feng Chu, Yu-Me Lin, Sui-Lung Su, Kuo-Cheng Lu, Jin-Shuen Chen, Fung-Chang Sung, Chien-Te Lee, Yu Yang, Shang-Jyh Hwang, Ming-Cheng Wang, Yung-Ho Hsu, Hung-Yi Chiou, Senyeong Kao, Yuh-Feng Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa2b384bea2a498887f8f8fd83eb484b
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spelling	oai:doaj.org-article:fa2b384bea2a498887f8f8fd83eb484b2021-12-02T15:08:28ZRelationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population10.1038/s41598-018-24757-62045-2322https://doaj.org/article/fa2b384bea2a498887f8f8fd83eb484b2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24757-6https://doaj.org/toc/2045-2322Abstract This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008–2013) and National Health Insurance Research Database (2001–2013). A total of 7357 patients with CKD aged 20–85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.Tian-Jong ChangCai-Mei ZhengMei-Yi WuTzu-Ting ChenYun-Chun WuYi-Lien WuHsin-Ting LinJing-Quan ZhengNain-Feng ChuYu-Me LinSui-Lung SuKuo-Cheng LuJin-Shuen ChenFung-Chang SungChien-Te LeeYu YangShang-Jyh HwangMing-Cheng WangYung-Ho HsuHung-Yi ChiouSenyeong KaoYuh-Feng LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tian-Jong Chang Cai-Mei Zheng Mei-Yi Wu Tzu-Ting Chen Yun-Chun Wu Yi-Lien Wu Hsin-Ting Lin Jing-Quan Zheng Nain-Feng Chu Yu-Me Lin Sui-Lung Su Kuo-Cheng Lu Jin-Shuen Chen Fung-Chang Sung Chien-Te Lee Yu Yang Shang-Jyh Hwang Ming-Cheng Wang Yung-Ho Hsu Hung-Yi Chiou Senyeong Kao Yuh-Feng Lin Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population
description	Abstract This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008–2013) and National Health Insurance Research Database (2001–2013). A total of 7357 patients with CKD aged 20–85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.
format	article
author	Tian-Jong Chang Cai-Mei Zheng Mei-Yi Wu Tzu-Ting Chen Yun-Chun Wu Yi-Lien Wu Hsin-Ting Lin Jing-Quan Zheng Nain-Feng Chu Yu-Me Lin Sui-Lung Su Kuo-Cheng Lu Jin-Shuen Chen Fung-Chang Sung Chien-Te Lee Yu Yang Shang-Jyh Hwang Ming-Cheng Wang Yung-Ho Hsu Hung-Yi Chiou Senyeong Kao Yuh-Feng Lin
author_facet	Tian-Jong Chang Cai-Mei Zheng Mei-Yi Wu Tzu-Ting Chen Yun-Chun Wu Yi-Lien Wu Hsin-Ting Lin Jing-Quan Zheng Nain-Feng Chu Yu-Me Lin Sui-Lung Su Kuo-Cheng Lu Jin-Shuen Chen Fung-Chang Sung Chien-Te Lee Yu Yang Shang-Jyh Hwang Ming-Cheng Wang Yung-Ho Hsu Hung-Yi Chiou Senyeong Kao Yuh-Feng Lin
author_sort	Tian-Jong Chang
title	Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population
title_short	Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population
title_full	Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population
title_fullStr	Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population
title_full_unstemmed	Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population
title_sort	relationship between body mass index and renal function deterioration among the taiwanese chronic kidney disease population
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fa2b384bea2a498887f8f8fd83eb484b
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Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population

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