Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses

Radiofrequency ablation (RFA) is a minimally invasive tumor ablation method, however incomplete ablation and the induction of an immunosuppressive microenvironment limit its efficacy in the clinic. Here the authors design a pH-responsive lipoxidase-loaded nanoreactor, that by triggering ferroptosis...

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Autores principales:	Zhijuan Yang, Yujie Zhu, Ziliang Dong, Wei Li, Nailin Yang, Xianwen Wang, Liangzhu Feng, Zhuang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa30c8364593490fb49d0639af6c5c32
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spelling	oai:doaj.org-article:fa30c8364593490fb49d0639af6c5c322021-12-02T17:01:29ZTumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses10.1038/s41467-021-24604-92041-1723https://doaj.org/article/fa30c8364593490fb49d0639af6c5c322021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24604-9https://doaj.org/toc/2041-1723Radiofrequency ablation (RFA) is a minimally invasive tumor ablation method, however incomplete ablation and the induction of an immunosuppressive microenvironment limit its efficacy in the clinic. Here the authors design a pH-responsive lipoxidase-loaded nanoreactor, that by triggering ferroptosis and anti-tumor immunity, amplify the therapeutic benefits of RFA in preclinical models.Zhijuan YangYujie ZhuZiliang DongWei LiNailin YangXianwen WangLiangzhu FengZhuang LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhijuan Yang Yujie Zhu Ziliang Dong Wei Li Nailin Yang Xianwen Wang Liangzhu Feng Zhuang Liu Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses
description	Radiofrequency ablation (RFA) is a minimally invasive tumor ablation method, however incomplete ablation and the induction of an immunosuppressive microenvironment limit its efficacy in the clinic. Here the authors design a pH-responsive lipoxidase-loaded nanoreactor, that by triggering ferroptosis and anti-tumor immunity, amplify the therapeutic benefits of RFA in preclinical models.
format	article
author	Zhijuan Yang Yujie Zhu Ziliang Dong Wei Li Nailin Yang Xianwen Wang Liangzhu Feng Zhuang Liu
author_facet	Zhijuan Yang Yujie Zhu Ziliang Dong Wei Li Nailin Yang Xianwen Wang Liangzhu Feng Zhuang Liu
author_sort	Zhijuan Yang
title	Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses
title_short	Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses
title_full	Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses
title_fullStr	Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses
title_full_unstemmed	Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses
title_sort	tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa30c8364593490fb49d0639af6c5c32
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Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses

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