Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus

Shidong Tan,1 Guangyao Zang,1 Ying Wang,1 Zhen Sun,1 Yalan Li,1 Cheng Lu,2 Zhongqun Wang1 1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2General Office, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of ChinaCorr...

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Autores principales:	Tan S, Zang G, Wang Y, Sun Z, Li Y, Lu C, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetes mellitus tumor angiogenesis differences；tumor microenvironment；hypoxia Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/fa31895718ac4e77af8ed99a3b4635b3
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spelling	oai:doaj.org-article:fa31895718ac4e77af8ed99a3b4635b32021-12-02T16:27:19ZDifferences of Angiogenesis Factors in Tumor and Diabetes Mellitus1178-7007https://doaj.org/article/fa31895718ac4e77af8ed99a3b4635b32021-07-01T00:00:00Zhttps://www.dovepress.com/differences-of-angiogenesis-factors-in-tumor-and-diabetes-mellitus-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Shidong Tan,1 Guangyao Zang,1 Ying Wang,1 Zhen Sun,1 Yalan Li,1 Cheng Lu,2 Zhongqun Wang1 1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2General Office, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of ChinaCorrespondence: Cheng LuGeneral Office, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, 212001, People’s Republic of China, +86 511 88986902Email jdfylz@sina.comZhongqun WangDepartment of Cardiology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, 212001, People’s Republic of ChinaTel +86 511 85030586Email wangtsmc@126.comAbstract: Angiogenesis, as a process occurring under the regulation of a variety of factors, is one of the important ways of vascular development. It coexists in a variety of pathological and physiological processes. Now a large number of studies have proved that tumor growth, metastasis, and various vascular complications of diabetes are closely related to angiogenesis, and an increasing number of studies have shown that there are many common factors between the two. But angiogenesis is the opposite of the two: it is enhanced in tumors and suppressed in diabetes. Therefore, this review discusses the causes of the phenomenon from the expression of various factors affecting angiogenesis in these two diseases and their effects on angiogenesis in the relevant microenvironment, as well as the application status of these factors or cells as therapeutic targets in the treatment of these two diseases.Keywords: diabetes mellitus, tumor, angiogenesis, differences, tumor microenvironment, hypoxiaTan SZang GWang YSun ZLi YLu CWang ZDove Medical Pressarticlediabetes mellitustumorangiogenesisdifferences；tumor microenvironment；hypoxiaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3375-3388 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus tumor angiogenesis differences；tumor microenvironment；hypoxia Specialties of internal medicine RC581-951
spellingShingle	diabetes mellitus tumor angiogenesis differences；tumor microenvironment；hypoxia Specialties of internal medicine RC581-951 Tan S Zang G Wang Y Sun Z Li Y Lu C Wang Z Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus
description	Shidong Tan,1 Guangyao Zang,1 Ying Wang,1 Zhen Sun,1 Yalan Li,1 Cheng Lu,2 Zhongqun Wang1 1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2General Office, Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of ChinaCorrespondence: Cheng LuGeneral Office, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, 212001, People’s Republic of China, +86 511 88986902Email jdfylz@sina.comZhongqun WangDepartment of Cardiology, Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang, 212001, People’s Republic of ChinaTel +86 511 85030586Email wangtsmc@126.comAbstract: Angiogenesis, as a process occurring under the regulation of a variety of factors, is one of the important ways of vascular development. It coexists in a variety of pathological and physiological processes. Now a large number of studies have proved that tumor growth, metastasis, and various vascular complications of diabetes are closely related to angiogenesis, and an increasing number of studies have shown that there are many common factors between the two. But angiogenesis is the opposite of the two: it is enhanced in tumors and suppressed in diabetes. Therefore, this review discusses the causes of the phenomenon from the expression of various factors affecting angiogenesis in these two diseases and their effects on angiogenesis in the relevant microenvironment, as well as the application status of these factors or cells as therapeutic targets in the treatment of these two diseases.Keywords: diabetes mellitus, tumor, angiogenesis, differences, tumor microenvironment, hypoxia
format	article
author	Tan S Zang G Wang Y Sun Z Li Y Lu C Wang Z
author_facet	Tan S Zang G Wang Y Sun Z Li Y Lu C Wang Z
author_sort	Tan S
title	Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus
title_short	Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus
title_full	Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus
title_fullStr	Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus
title_full_unstemmed	Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus
title_sort	differences of angiogenesis factors in tumor and diabetes mellitus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/fa31895718ac4e77af8ed99a3b4635b3
work_keys_str_mv	AT tans differencesofangiogenesisfactorsintumoranddiabetesmellitus AT zangg differencesofangiogenesisfactorsintumoranddiabetesmellitus AT wangy differencesofangiogenesisfactorsintumoranddiabetesmellitus AT sunz differencesofangiogenesisfactorsintumoranddiabetesmellitus AT liy differencesofangiogenesisfactorsintumoranddiabetesmellitus AT luc differencesofangiogenesisfactorsintumoranddiabetesmellitus AT wangz differencesofangiogenesisfactorsintumoranddiabetesmellitus
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Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus

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