Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome

ABSTRACT Nonhealing chronic wounds are all unique in origin and circumstance, and attempting to isolate a single etiology for the failure of a wound to heal is daunting. Wounds represent complex systems of multispecies fungal and bacterial biofilms. The survival strategies of interactive microbial c...

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Autor principal:	Mahmoud Ghannoum
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/fa34aa5ea5ab49008b7e9d7f0f573053
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spelling	oai:doaj.org-article:fa34aa5ea5ab49008b7e9d7f0f5730532021-11-15T15:50:17ZCooperative Evolutionary Strategy between the Bacteriome and Mycobiome10.1128/mBio.01951-162150-7511https://doaj.org/article/fa34aa5ea5ab49008b7e9d7f0f5730532016-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01951-16https://doaj.org/toc/2150-7511ABSTRACT Nonhealing chronic wounds are all unique in origin and circumstance, and attempting to isolate a single etiology for the failure of a wound to heal is daunting. Wounds represent complex systems of multispecies fungal and bacterial biofilms. The survival strategies of interactive microbial communities have led to cooperative evolutionary strategies that culminate in biofilm formation. In microbial dysbiosis, biofilms are beneficial to both bacterial and fungal communities but detrimental to the host. Fungi benefit by a surge in their virulence factors, while bacteria become tolerant to antibacterials as a consequence of living under the protective umbrella of the biofilm matrix. This interkingdom cooperation negatively impacts the host, as the fungi and bacteria produce extracellular enzymes that inflict tissue damage, leading to an increase in proinflammatory cytokines, which results in oxidative damage and apoptotic cell death.Mahmoud GhannoumAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Mahmoud Ghannoum Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome
description	ABSTRACT Nonhealing chronic wounds are all unique in origin and circumstance, and attempting to isolate a single etiology for the failure of a wound to heal is daunting. Wounds represent complex systems of multispecies fungal and bacterial biofilms. The survival strategies of interactive microbial communities have led to cooperative evolutionary strategies that culminate in biofilm formation. In microbial dysbiosis, biofilms are beneficial to both bacterial and fungal communities but detrimental to the host. Fungi benefit by a surge in their virulence factors, while bacteria become tolerant to antibacterials as a consequence of living under the protective umbrella of the biofilm matrix. This interkingdom cooperation negatively impacts the host, as the fungi and bacteria produce extracellular enzymes that inflict tissue damage, leading to an increase in proinflammatory cytokines, which results in oxidative damage and apoptotic cell death.
format	article
author	Mahmoud Ghannoum
author_facet	Mahmoud Ghannoum
author_sort	Mahmoud Ghannoum
title	Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome
title_short	Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome
title_full	Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome
title_fullStr	Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome
title_full_unstemmed	Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome
title_sort	cooperative evolutionary strategy between the bacteriome and mycobiome
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/fa34aa5ea5ab49008b7e9d7f0f573053
work_keys_str_mv	AT mahmoudghannoum cooperativeevolutionarystrategybetweenthebacteriomeandmycobiome
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Cooperative Evolutionary Strategy between the Bacteriome and Mycobiome

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