Complementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections
The ubiquitous mold Aspergillus fumigatus is the major etiologic agent of invasive aspergillosis, a life-threatening infection amongst immune compromised individuals. An increasing body of evidence indicates that effective disposal of A. fumigatus requires the coordinate action of both cellular and...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:fa369c147d414d2a8dab320f9ab105b52021-11-18T08:43:18ZComplementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections1664-322410.3389/fimmu.2021.785883https://doaj.org/article/fa369c147d414d2a8dab320f9ab105b52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.785883/fullhttps://doaj.org/toc/1664-3224The ubiquitous mold Aspergillus fumigatus is the major etiologic agent of invasive aspergillosis, a life-threatening infection amongst immune compromised individuals. An increasing body of evidence indicates that effective disposal of A. fumigatus requires the coordinate action of both cellular and humoral components of the innate immune system. Early recognition of the fungal pathogen, in particular, is mediated by a set of diverse soluble pattern recognition molecules (PRMs) that act as “ancestral antibodies” inasmuch as they are endowed with opsonic, pro-phagocytic and killing properties. Pivotal is, in this respect, the contribution of the complement system, which functionally cooperates with cell-borne pattern recognition receptors (PRRs) and other soluble PRMs, including pentraxins. Indeed, complement and pentraxins form an integrated system with crosstalk, synergism, and regulation, which stands as a paradigm of the interplay between PRMs in the mounting and orchestration of antifungal immunity. Following upon our past experience with the long pentraxin PTX3, a well-established immune effector in the host response to A. fumigatus, we recently reported that this fungal pathogen is targeted in vitro and in vivo by the short pentraxin Serum Amyloid P component (SAP) too. Similar to PTX3, SAP promotes phagocytosis and disposal of the fungal pathogen via complement-dependent pathways. However, the two proteins exploit different mechanisms of complement activation and receptor-mediated phagocytosis, which further extends complexity and integration of the complement-pentraxin crosstalk in the immune response to A. fumigatus. Here we revisit this crosstalk in light of the emerging roles of SAP as a novel PRM with antifungal activity.Raffaella ParenteValentina PossettiMarco ErreniMarco ErreniFrancesca D’AutiliaBarbara BottazziCecilia GarlandaCecilia GarlandaAlberto MantovaniAlberto MantovaniAlberto MantovaniAntonio InforzatoAntonio InforzatoAndrea DoniFrontiers Media S.A.articleAspergillus fumigatusaspergillosisinnate immunitypentraxinscomplementImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Aspergillus fumigatus aspergillosis innate immunity pentraxins complement Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
Aspergillus fumigatus aspergillosis innate immunity pentraxins complement Immunologic diseases. Allergy RC581-607 Raffaella Parente Valentina Possetti Marco Erreni Marco Erreni Francesca D’Autilia Barbara Bottazzi Cecilia Garlanda Cecilia Garlanda Alberto Mantovani Alberto Mantovani Alberto Mantovani Antonio Inforzato Antonio Inforzato Andrea Doni Complementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections |
| description |
The ubiquitous mold Aspergillus fumigatus is the major etiologic agent of invasive aspergillosis, a life-threatening infection amongst immune compromised individuals. An increasing body of evidence indicates that effective disposal of A. fumigatus requires the coordinate action of both cellular and humoral components of the innate immune system. Early recognition of the fungal pathogen, in particular, is mediated by a set of diverse soluble pattern recognition molecules (PRMs) that act as “ancestral antibodies” inasmuch as they are endowed with opsonic, pro-phagocytic and killing properties. Pivotal is, in this respect, the contribution of the complement system, which functionally cooperates with cell-borne pattern recognition receptors (PRRs) and other soluble PRMs, including pentraxins. Indeed, complement and pentraxins form an integrated system with crosstalk, synergism, and regulation, which stands as a paradigm of the interplay between PRMs in the mounting and orchestration of antifungal immunity. Following upon our past experience with the long pentraxin PTX3, a well-established immune effector in the host response to A. fumigatus, we recently reported that this fungal pathogen is targeted in vitro and in vivo by the short pentraxin Serum Amyloid P component (SAP) too. Similar to PTX3, SAP promotes phagocytosis and disposal of the fungal pathogen via complement-dependent pathways. However, the two proteins exploit different mechanisms of complement activation and receptor-mediated phagocytosis, which further extends complexity and integration of the complement-pentraxin crosstalk in the immune response to A. fumigatus. Here we revisit this crosstalk in light of the emerging roles of SAP as a novel PRM with antifungal activity. |
| format |
article |
| author |
Raffaella Parente Valentina Possetti Marco Erreni Marco Erreni Francesca D’Autilia Barbara Bottazzi Cecilia Garlanda Cecilia Garlanda Alberto Mantovani Alberto Mantovani Alberto Mantovani Antonio Inforzato Antonio Inforzato Andrea Doni |
| author_facet |
Raffaella Parente Valentina Possetti Marco Erreni Marco Erreni Francesca D’Autilia Barbara Bottazzi Cecilia Garlanda Cecilia Garlanda Alberto Mantovani Alberto Mantovani Alberto Mantovani Antonio Inforzato Antonio Inforzato Andrea Doni |
| author_sort |
Raffaella Parente |
| title |
Complementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections |
| title_short |
Complementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections |
| title_full |
Complementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections |
| title_fullStr |
Complementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections |
| title_full_unstemmed |
Complementary Roles of Short and Long Pentraxins in the Complement-Mediated Immune Response to Aspergillus fumigatus Infections |
| title_sort |
complementary roles of short and long pentraxins in the complement-mediated immune response to aspergillus fumigatus infections |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/fa369c147d414d2a8dab320f9ab105b5 |
| work_keys_str_mv |
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