Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis

Menna M Abdellatif,1 Islam A Khalil,2 Yara E Elakkad,2 Hesham A Eliwa,3 Tamer M Samir,4 Asmaa K Al-Mokaddem5 1Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt; 2Department of Pharmaceutics, College o...

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Autores principales:	Abdellatif MM, Khalil IA, Elakkad YE, Eliwa HA, Samir TM, Al-Mokaddem AK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	sertaconazole nitrate vaginal candidiasis mucoadhesive liposomes. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/fa3770a744bf47b2b5491ac9de746e95
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spelling	oai:doaj.org-article:fa3770a744bf47b2b5491ac9de746e952021-12-02T11:20:19ZFormulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis1178-2013https://doaj.org/article/fa3770a744bf47b2b5491ac9de746e952020-06-01T00:00:00Zhttps://www.dovepress.com/formulation-and-characterization-of-sertaconazole-nitrate-mucoadhesive-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Menna M Abdellatif,1 Islam A Khalil,2 Yara E Elakkad,2 Hesham A Eliwa,3 Tamer M Samir,4 Asmaa K Al-Mokaddem5 1Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt; 2Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt; 3Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt; 4Department of Microbiology and Immunology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt; 5Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptCorrespondence: Menna M Abdellatif Tel +201005647945Email dr.menna52@gmail.comPurpose: The aim of this study is to develop efficient localized therapy of sertaconazole nitrate for the treatment of vaginal candidiasis.Methods: Sertaconazole nitrate-loaded cationic liposomes were prepared by thin-film hydration method and coated with different concentrations of pectin (0.05%, 0.1% and 0.2%) to develop mucoadhesive liposomes. The formulated mucoadhesive vesicles were characterized in terms of morphology, entrapment efficiency, particle size, zeta value, mucoadhesive properties and drug release. The selected formula was incorporated into a gel base and further characterized by an ex vivo permeation study in comparison with conventional sertaconazole gel. Also, the in vivo study was performed to assess the efficacy of sertaconazole mucoadhesive liposomal gel in treating rats with vaginal candidiasis.Results: The mucoadhesive liposomes were spherical. Coating liposomes with pectin results in increased entrapment efficiency and particle size compared with uncoated vesicles. On the contrary, zeta values were reduced upon coating liposomes with pectin indicating efficient coating of liposomes with pectin. Mucoadhesive liposomes showed a more prolonged and sustained drug release compared with uncoated liposomes. Ex vivo study results showed that mucoadhesive liposomal gel increased sertaconazole tissue retention and reduced drug tissue penetration. In the invivo study, the mucoadhesive liposomal gel showed a significant reduction in the microbial count with a subsequent reduction in inflammatory responses with the lowest histopathological change compared with conventional gel.Conclusion: The study confirmed the potentiality of employing mucoadhesive liposomes as a successful carrier for the vaginal delivery of antifungal drugs.Keywords: sertaconazole nitrate, vaginal candidiasis, mucoadhesive liposomesAbdellatif MMKhalil IAElakkad YEEliwa HASamir TMAl-Mokaddem AKDove Medical Pressarticlesertaconazole nitratevaginal candidiasismucoadhesive liposomes.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 4079-4090 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	sertaconazole nitrate vaginal candidiasis mucoadhesive liposomes. Medicine (General) R5-920
spellingShingle	sertaconazole nitrate vaginal candidiasis mucoadhesive liposomes. Medicine (General) R5-920 Abdellatif MM Khalil IA Elakkad YE Eliwa HA Samir TM Al-Mokaddem AK Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis
description	Menna M Abdellatif,1 Islam A Khalil,2 Yara E Elakkad,2 Hesham A Eliwa,3 Tamer M Samir,4 Asmaa K Al-Mokaddem5 1Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt; 2Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt; 3Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt; 4Department of Microbiology and Immunology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt; 5Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptCorrespondence: Menna M Abdellatif Tel +201005647945Email dr.menna52@gmail.comPurpose: The aim of this study is to develop efficient localized therapy of sertaconazole nitrate for the treatment of vaginal candidiasis.Methods: Sertaconazole nitrate-loaded cationic liposomes were prepared by thin-film hydration method and coated with different concentrations of pectin (0.05%, 0.1% and 0.2%) to develop mucoadhesive liposomes. The formulated mucoadhesive vesicles were characterized in terms of morphology, entrapment efficiency, particle size, zeta value, mucoadhesive properties and drug release. The selected formula was incorporated into a gel base and further characterized by an ex vivo permeation study in comparison with conventional sertaconazole gel. Also, the in vivo study was performed to assess the efficacy of sertaconazole mucoadhesive liposomal gel in treating rats with vaginal candidiasis.Results: The mucoadhesive liposomes were spherical. Coating liposomes with pectin results in increased entrapment efficiency and particle size compared with uncoated vesicles. On the contrary, zeta values were reduced upon coating liposomes with pectin indicating efficient coating of liposomes with pectin. Mucoadhesive liposomes showed a more prolonged and sustained drug release compared with uncoated liposomes. Ex vivo study results showed that mucoadhesive liposomal gel increased sertaconazole tissue retention and reduced drug tissue penetration. In the invivo study, the mucoadhesive liposomal gel showed a significant reduction in the microbial count with a subsequent reduction in inflammatory responses with the lowest histopathological change compared with conventional gel.Conclusion: The study confirmed the potentiality of employing mucoadhesive liposomes as a successful carrier for the vaginal delivery of antifungal drugs.Keywords: sertaconazole nitrate, vaginal candidiasis, mucoadhesive liposomes
format	article
author	Abdellatif MM Khalil IA Elakkad YE Eliwa HA Samir TM Al-Mokaddem AK
author_facet	Abdellatif MM Khalil IA Elakkad YE Eliwa HA Samir TM Al-Mokaddem AK
author_sort	Abdellatif MM
title	Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis
title_short	Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis
title_full	Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis
title_fullStr	Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis
title_full_unstemmed	Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis
title_sort	formulation and characterization of sertaconazole nitrate mucoadhesive liposomes for vaginal candidiasis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fa3770a744bf47b2b5491ac9de746e95
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Formulation and Characterization of Sertaconazole Nitrate Mucoadhesive Liposomes for Vaginal Candidiasis

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