Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus

While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications...

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Autores principales: Michael Habig, Cecile Lorrain, Alice Feurtey, Jovan Komluski, Eva H. Stukenbrock
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fa37710675714714949ef719ab46770f
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Sumario:While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications on mutation rates.