Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus

While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications...

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Autores principales:	Michael Habig, Cecile Lorrain, Alice Feurtey, Jovan Komluski, Eva H. Stukenbrock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa37710675714714949ef719ab46770f
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spelling	oai:doaj.org-article:fa37710675714714949ef719ab46770f2021-12-02T19:16:20ZEpigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus10.1038/s41467-021-26108-y2041-1723https://doaj.org/article/fa37710675714714949ef719ab46770f2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26108-yhttps://doaj.org/toc/2041-1723While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications on mutation rates.Michael HabigCecile LorrainAlice FeurteyJovan KomluskiEva H. StukenbrockNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Habig Cecile Lorrain Alice Feurtey Jovan Komluski Eva H. Stukenbrock Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
description	While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications on mutation rates.
format	article
author	Michael Habig Cecile Lorrain Alice Feurtey Jovan Komluski Eva H. Stukenbrock
author_facet	Michael Habig Cecile Lorrain Alice Feurtey Jovan Komluski Eva H. Stukenbrock
author_sort	Michael Habig
title	Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_short	Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_full	Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_fullStr	Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_full_unstemmed	Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_sort	epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa37710675714714949ef719ab46770f
work_keys_str_mv	AT michaelhabig epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus AT cecilelorrain epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus AT alicefeurtey epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus AT jovankomluski epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus AT evahstukenbrock epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus
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Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus

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