Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications...
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Nature Portfolio
2021
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oai:doaj.org-article:fa37710675714714949ef719ab46770f2021-12-02T19:16:20ZEpigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus10.1038/s41467-021-26108-y2041-1723https://doaj.org/article/fa37710675714714949ef719ab46770f2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26108-yhttps://doaj.org/toc/2041-1723While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications on mutation rates.Michael HabigCecile LorrainAlice FeurteyJovan KomluskiEva H. StukenbrockNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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Science Q Michael Habig Cecile Lorrain Alice Feurtey Jovan Komluski Eva H. Stukenbrock Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus |
description |
While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications on mutation rates. |
format |
article |
author |
Michael Habig Cecile Lorrain Alice Feurtey Jovan Komluski Eva H. Stukenbrock |
author_facet |
Michael Habig Cecile Lorrain Alice Feurtey Jovan Komluski Eva H. Stukenbrock |
author_sort |
Michael Habig |
title |
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus |
title_short |
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus |
title_full |
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus |
title_fullStr |
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus |
title_full_unstemmed |
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus |
title_sort |
epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/fa37710675714714949ef719ab46770f |
work_keys_str_mv |
AT michaelhabig epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus AT cecilelorrain epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus AT alicefeurtey epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus AT jovankomluski epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus AT evahstukenbrock epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus |
_version_ |
1718377008549855232 |