Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus

While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Michael Habig, Cecile Lorrain, Alice Feurtey, Jovan Komluski, Eva H. Stukenbrock
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/fa37710675714714949ef719ab46770f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:fa37710675714714949ef719ab46770f
record_format dspace
spelling oai:doaj.org-article:fa37710675714714949ef719ab46770f2021-12-02T19:16:20ZEpigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus10.1038/s41467-021-26108-y2041-1723https://doaj.org/article/fa37710675714714949ef719ab46770f2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26108-yhttps://doaj.org/toc/2041-1723While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications on mutation rates.Michael HabigCecile LorrainAlice FeurteyJovan KomluskiEva H. StukenbrockNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michael Habig
Cecile Lorrain
Alice Feurtey
Jovan Komluski
Eva H. Stukenbrock
Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
description While a correlation between epigenetic modifications and mutation rates has been observed, experimental evidence of causality is limited. Here the authors measure the mutation rate in fungal mutants lacking histone modifications and confirm experimentally a causal effect of epigenetic modifications on mutation rates.
format article
author Michael Habig
Cecile Lorrain
Alice Feurtey
Jovan Komluski
Eva H. Stukenbrock
author_facet Michael Habig
Cecile Lorrain
Alice Feurtey
Jovan Komluski
Eva H. Stukenbrock
author_sort Michael Habig
title Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_short Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_full Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_fullStr Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_full_unstemmed Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
title_sort epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fa37710675714714949ef719ab46770f
work_keys_str_mv AT michaelhabig epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus
AT cecilelorrain epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus
AT alicefeurtey epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus
AT jovankomluski epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus
AT evahstukenbrock epigeneticmodificationsaffecttherateofspontaneousmutationsinapathogenicfungus
_version_ 1718377008549855232