Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure

Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Filmon Beyenne Demoz Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin Tafere P.O. Box: 1871, Mekelle, EthiopiaTel +251-908822323Email gebrehiwotg07@gmail.c...

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Autores principales:	Tafere GG, Wondafrash DZ, Demoz FB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	n-acetylcysteine dengue virus acute liver failure Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/fa38bf51a8684854bffacfb764ddbbb5
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spelling	oai:doaj.org-article:fa38bf51a8684854bffacfb764ddbbb52021-12-02T11:22:39ZRepurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure1179-1535https://doaj.org/article/fa38bf51a8684854bffacfb764ddbbb52020-11-01T00:00:00Zhttps://www.dovepress.com/repurposing-of-n-acetylcysteine-for-the-treatment-of-dengue-virus-indu-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Filmon Beyenne Demoz Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin Tafere P.O. Box: 1871, Mekelle, EthiopiaTel +251-908822323Email gebrehiwotg07@gmail.comAbstract: The prevalence of dengue infection-induced acute liver damage is increasing from time to time. Since it has no specific antiviral treatment in the world, people in endemic areas suffer more from dengue disorders. Thus, there is a need for searching options for the treatment of dengue-induced acute liver failure. N-acetylcysteine, which is used for the treatment of nasal congestion disorder and paracetamol overdose toxicity, could be used as a definitive therapy for dengue virus-induced acute liver disease. Therefore, this review discusses the therapeutic use of N-acetylcysteine for dengue-induced acute liver disease. Various case reports and case series showed that patients received NAC recovered from their clinical status. Additionally, a preclinical study showed that N-acetylcysteine has anti-dengue virus activity. Thus, N-acetylcysteine could be used as a definitive therapy in dengue virus-induced hepatitis. This might encourage researchers to further investigate the importance of N-acetylcysteine for dengue virus-induced hepatitis.Keywords: N-acetylcysteine, dengue virus, acute liver failureTafere GGWondafrash DZDemoz FBDove Medical Pressarticlen-acetylcysteinedengue virusacute liver failureDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 12, Pp 173-178 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	n-acetylcysteine dengue virus acute liver failure Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	n-acetylcysteine dengue virus acute liver failure Diseases of the digestive system. Gastroenterology RC799-869 Tafere GG Wondafrash DZ Demoz FB Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure
description	Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Filmon Beyenne Demoz Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin Tafere P.O. Box: 1871, Mekelle, EthiopiaTel +251-908822323Email gebrehiwotg07@gmail.comAbstract: The prevalence of dengue infection-induced acute liver damage is increasing from time to time. Since it has no specific antiviral treatment in the world, people in endemic areas suffer more from dengue disorders. Thus, there is a need for searching options for the treatment of dengue-induced acute liver failure. N-acetylcysteine, which is used for the treatment of nasal congestion disorder and paracetamol overdose toxicity, could be used as a definitive therapy for dengue virus-induced acute liver disease. Therefore, this review discusses the therapeutic use of N-acetylcysteine for dengue-induced acute liver disease. Various case reports and case series showed that patients received NAC recovered from their clinical status. Additionally, a preclinical study showed that N-acetylcysteine has anti-dengue virus activity. Thus, N-acetylcysteine could be used as a definitive therapy in dengue virus-induced hepatitis. This might encourage researchers to further investigate the importance of N-acetylcysteine for dengue virus-induced hepatitis.Keywords: N-acetylcysteine, dengue virus, acute liver failure
format	article
author	Tafere GG Wondafrash DZ Demoz FB
author_facet	Tafere GG Wondafrash DZ Demoz FB
author_sort	Tafere GG
title	Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure
title_short	Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure
title_full	Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure
title_fullStr	Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure
title_full_unstemmed	Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure
title_sort	repurposing of n-acetylcysteine for the treatment of dengue virus-induced acute liver failure
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/fa38bf51a8684854bffacfb764ddbbb5
work_keys_str_mv	AT taferegg repurposingofnacetylcysteineforthetreatmentofdenguevirusinducedacuteliverfailure AT wondafrashdz repurposingofnacetylcysteineforthetreatmentofdenguevirusinducedacuteliverfailure AT demozfb repurposingofnacetylcysteineforthetreatmentofdenguevirusinducedacuteliverfailure
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Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure

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