Gait analysis may distinguish progressive supranuclear palsy and Parkinson disease since the earliest stages

Abstract Progressive supranuclear palsy (PSP) is a rare and rapidly progressing atypical parkinsonism. Albeit existing clinical criteria for PSP have good specificity and sensitivity, there is a need for biomarkers able to capture early objective disease-specific abnormalities. This study aimed to i...

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Autores principales:	Marianna Amboni, Carlo Ricciardi, Marina Picillo, Chiara De Santis, Gianluca Ricciardelli, Filomena Abate, Maria Francesca Tepedino, Giovanni D’Addio, Giuseppe Cesarelli, Giampiero Volpe, Maria Consiglia Calabrese, Mario Cesarelli, Paolo Barone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa390d462e7943688220817ee1b4d75d
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spelling	oai:doaj.org-article:fa390d462e7943688220817ee1b4d75d2021-12-02T16:55:24ZGait analysis may distinguish progressive supranuclear palsy and Parkinson disease since the earliest stages10.1038/s41598-021-88877-22045-2322https://doaj.org/article/fa390d462e7943688220817ee1b4d75d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88877-2https://doaj.org/toc/2045-2322Abstract Progressive supranuclear palsy (PSP) is a rare and rapidly progressing atypical parkinsonism. Albeit existing clinical criteria for PSP have good specificity and sensitivity, there is a need for biomarkers able to capture early objective disease-specific abnormalities. This study aimed to identify gait patterns specifically associated with early PSP. The study population comprised 104 consecutively enrolled participants (83 PD and 21 PSP patients). Gait was investigated using a gait analysis system during normal gait and a cognitive dual task. Univariate statistical analysis and binary logistic regression were used to compare all PD patients and all PSP patients, as well as newly diagnosed PD and early PSP patients. Gait pattern was poorer in PSP patients than in PD patients, even from early stages. PSP patients exhibited reduced velocity and increased measures of dynamic instability when compared to PD patients. Application of predictive models to gait data revealed that PD gait pattern was typified by increased cadence and longer cycle length, whereas a longer stance phase characterized PSP patients in both mid and early disease stages. The present study demonstrates that quantitative gait evaluation clearly distinguishes PSP patients from PD patients since the earliest stages of disease. First, this might candidate gait analysis as a reliable biomarker in both clinical and research setting. Furthermore, our results may offer speculative clues for conceiving early disease-specific rehabilitation strategies.Marianna AmboniCarlo RicciardiMarina PicilloChiara De SantisGianluca RicciardelliFilomena AbateMaria Francesca TepedinoGiovanni D’AddioGiuseppe CesarelliGiampiero VolpeMaria Consiglia CalabreseMario CesarelliPaolo BaroneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marianna Amboni Carlo Ricciardi Marina Picillo Chiara De Santis Gianluca Ricciardelli Filomena Abate Maria Francesca Tepedino Giovanni D’Addio Giuseppe Cesarelli Giampiero Volpe Maria Consiglia Calabrese Mario Cesarelli Paolo Barone Gait analysis may distinguish progressive supranuclear palsy and Parkinson disease since the earliest stages
description	Abstract Progressive supranuclear palsy (PSP) is a rare and rapidly progressing atypical parkinsonism. Albeit existing clinical criteria for PSP have good specificity and sensitivity, there is a need for biomarkers able to capture early objective disease-specific abnormalities. This study aimed to identify gait patterns specifically associated with early PSP. The study population comprised 104 consecutively enrolled participants (83 PD and 21 PSP patients). Gait was investigated using a gait analysis system during normal gait and a cognitive dual task. Univariate statistical analysis and binary logistic regression were used to compare all PD patients and all PSP patients, as well as newly diagnosed PD and early PSP patients. Gait pattern was poorer in PSP patients than in PD patients, even from early stages. PSP patients exhibited reduced velocity and increased measures of dynamic instability when compared to PD patients. Application of predictive models to gait data revealed that PD gait pattern was typified by increased cadence and longer cycle length, whereas a longer stance phase characterized PSP patients in both mid and early disease stages. The present study demonstrates that quantitative gait evaluation clearly distinguishes PSP patients from PD patients since the earliest stages of disease. First, this might candidate gait analysis as a reliable biomarker in both clinical and research setting. Furthermore, our results may offer speculative clues for conceiving early disease-specific rehabilitation strategies.
format	article
author	Marianna Amboni Carlo Ricciardi Marina Picillo Chiara De Santis Gianluca Ricciardelli Filomena Abate Maria Francesca Tepedino Giovanni D’Addio Giuseppe Cesarelli Giampiero Volpe Maria Consiglia Calabrese Mario Cesarelli Paolo Barone
author_facet	Marianna Amboni Carlo Ricciardi Marina Picillo Chiara De Santis Gianluca Ricciardelli Filomena Abate Maria Francesca Tepedino Giovanni D’Addio Giuseppe Cesarelli Giampiero Volpe Maria Consiglia Calabrese Mario Cesarelli Paolo Barone
author_sort	Marianna Amboni
title	Gait analysis may distinguish progressive supranuclear palsy and Parkinson disease since the earliest stages
title_short	Gait analysis may distinguish progressive supranuclear palsy and Parkinson disease since the earliest stages
title_full	Gait analysis may distinguish progressive supranuclear palsy and Parkinson disease since the earliest stages
title_fullStr	Gait analysis may distinguish progressive supranuclear palsy and Parkinson disease since the earliest stages
title_full_unstemmed	Gait analysis may distinguish progressive supranuclear palsy and Parkinson disease since the earliest stages
title_sort	gait analysis may distinguish progressive supranuclear palsy and parkinson disease since the earliest stages
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa390d462e7943688220817ee1b4d75d
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Gait analysis may distinguish progressive supranuclear palsy and Parkinson disease since the earliest stages

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