Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

The AcrB module of the AcrAB-TolC multidrug efflux pump sequesters drugs from the periplasm and outer leaflet of the inner membrane. Here, Oswaldet al. provide evidence that lipophilic carboxylated substrates bind to a groove between transmembrane helices TM1 and TM2, for further transport by an upw...

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Autores principales:	Christine Oswald, Heng-Keat Tam, Klaas M. Pos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa3b0c6a09c14ed89a4c26f47061ebab
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spelling	oai:doaj.org-article:fa3b0c6a09c14ed89a4c26f47061ebab2021-12-02T16:57:18ZTransport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB10.1038/ncomms138192041-1723https://doaj.org/article/fa3b0c6a09c14ed89a4c26f47061ebab2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13819https://doaj.org/toc/2041-1723The AcrB module of the AcrAB-TolC multidrug efflux pump sequesters drugs from the periplasm and outer leaflet of the inner membrane. Here, Oswaldet al. provide evidence that lipophilic carboxylated substrates bind to a groove between transmembrane helices TM1 and TM2, for further transport by an upward movement of TM2.Christine OswaldHeng-Keat TamKlaas M. PosNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christine Oswald Heng-Keat Tam Klaas M. Pos Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB
description	The AcrB module of the AcrAB-TolC multidrug efflux pump sequesters drugs from the periplasm and outer leaflet of the inner membrane. Here, Oswaldet al. provide evidence that lipophilic carboxylated substrates bind to a groove between transmembrane helices TM1 and TM2, for further transport by an upward movement of TM2.
format	article
author	Christine Oswald Heng-Keat Tam Klaas M. Pos
author_facet	Christine Oswald Heng-Keat Tam Klaas M. Pos
author_sort	Christine Oswald
title	Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB
title_short	Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB
title_full	Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB
title_fullStr	Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB
title_full_unstemmed	Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB
title_sort	transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter acrb
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/fa3b0c6a09c14ed89a4c26f47061ebab
work_keys_str_mv	AT christineoswald transportoflipophiliccarboxylatesismediatedbytransmembranehelix2inmultidrugtransporteracrb AT hengkeattam transportoflipophiliccarboxylatesismediatedbytransmembranehelix2inmultidrugtransporteracrb AT klaasmpos transportoflipophiliccarboxylatesismediatedbytransmembranehelix2inmultidrugtransporteracrb
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Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

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