Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB
The AcrB module of the AcrAB-TolC multidrug efflux pump sequesters drugs from the periplasm and outer leaflet of the inner membrane. Here, Oswaldet al. provide evidence that lipophilic carboxylated substrates bind to a groove between transmembrane helices TM1 and TM2, for further transport by an upw...
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| Auteurs principaux: | , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2016
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| Accès en ligne: | https://doaj.org/article/fa3b0c6a09c14ed89a4c26f47061ebab |
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