Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway

Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway

Abstract Background Chimeric antigen receptor T (CAR-T) cell therapy has limited effects in the treatment of solid tumors. Sulforaphane (SFN) is known to play an important role in inhibiting tumor growth, but its effect on CAR-T cells remains unclear. The goal of the current study was to determine w...

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Autores principales: Chunyi Shen, Zhen Zhang, Yonggui Tian, Feng Li, Lingxiao Zhou, Wenyi Jiang, Li Yang, Bin Zhang, Liping Wang, Yi Zhang
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Sulforaphane
Chimeric antigen receptor T cells
Programmed cell death 1
Programmed cell death ligand 1
Antitumor response
Medicine
R
Acceso en línea:https://doaj.org/article/fa4414bc3272439a9714929ad02b2689
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https://doaj.org/article/fa4414bc3272439a9714929ad02b2689

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