Perceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: A pilot observational cohort study.

<h4>Background</h4>Screening for changes in pregnancy-related anxiety and depressive symptoms during pregnancy may further our understanding of the relationship between these two variables and preterm birth.<h4>Objectives</h4>To determine whether changes in pregnancy-related...

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Autores principales:	Sharifa Lalani, Aliyah Dosani, Ntonghanwah Forcheh, Shahirose Sadrudin Premji, Sana Siddiqui, Kiran Shaikh, Ayesha Mian, Ilona S Yim, Maternal-infant Global Health Team (MiGHT) Collaborators in Research
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa45e383832a47b4be2f20d0357b6e5c
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spelling	oai:doaj.org-article:fa45e383832a47b4be2f20d0357b6e5c2021-11-25T06:19:20ZPerceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: A pilot observational cohort study.1932-620310.1371/journal.pone.0250982https://doaj.org/article/fa45e383832a47b4be2f20d0357b6e5c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0250982https://doaj.org/toc/1932-6203<h4>Background</h4>Screening for changes in pregnancy-related anxiety and depressive symptoms during pregnancy may further our understanding of the relationship between these two variables and preterm birth.<h4>Objectives</h4>To determine whether changes in pregnancy-related anxiety and depressive symptoms during pregnancy influence the risk of preterm birth among Pakistani women; explore whether perceived stress moderates or mediates this relationship, and examine the relationship between the various components of pregnancy-related anxiety and preterm birth.<h4>Methods</h4>A prospective cohort study design was used to recruit a diverse sample of 300 low-risk pregnant women from four centers of Aga Khan Hospital for Women and Children in Karachi, Pakistan. Changes in pregnancy-related anxiety and depressive symptoms during pregnancy were tested. Multiple logistic regression analysis was used to determine a predictive model for preterm birth. We then determined if the influence of perceived stress could moderate or mediate the effect of depressive symptoms on preterm birth.<h4>Results</h4>Changes in pregnancy-related anxiety (OR = 1.1, CI 0.97-1.17, p = 0.167) and depressive symptoms (OR = 0.9, CI 0.85-1.03, p = 0.179) were insignificant as predictors of preterm birth after adjusting for the effects of maternal education and family type. When perceived stress was added into the model, we found that changes in depressive symptoms became marginally significant after adjusting for covariates (OR = 0.9, CI 0.82-1.01, p = 0.082). After adjusting for the mediation effect of change in perceived stress, the effect of change in depressive symptoms on preterm birth were marginally significant after adjusting for covariates. Among six different dimensions of pregnancy-related anxiety, mother's concerns about fetal health showed a trend towards being predictive of preterm birth (OR = 1.3, CI 0.97-1.72, p = 0.078).<h4>Conclusions</h4>There may be a relationship between perceived stress and antenatal depressive symptoms and preterm birth. This is the first study of its kind to be conducted in Pakistan. Further research is required to validate these results.Sharifa LalaniAliyah DosaniNtonghanwah ForchehShahirose Sadrudin PremjiSana SiddiquiKiran ShaikhAyesha MianIlona S YimMaternal-infant Global Health Team (MiGHT) Collaborators in ResearchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0250982 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sharifa Lalani Aliyah Dosani Ntonghanwah Forcheh Shahirose Sadrudin Premji Sana Siddiqui Kiran Shaikh Ayesha Mian Ilona S Yim Maternal-infant Global Health Team (MiGHT) Collaborators in Research Perceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: A pilot observational cohort study.
description	<h4>Background</h4>Screening for changes in pregnancy-related anxiety and depressive symptoms during pregnancy may further our understanding of the relationship between these two variables and preterm birth.<h4>Objectives</h4>To determine whether changes in pregnancy-related anxiety and depressive symptoms during pregnancy influence the risk of preterm birth among Pakistani women; explore whether perceived stress moderates or mediates this relationship, and examine the relationship between the various components of pregnancy-related anxiety and preterm birth.<h4>Methods</h4>A prospective cohort study design was used to recruit a diverse sample of 300 low-risk pregnant women from four centers of Aga Khan Hospital for Women and Children in Karachi, Pakistan. Changes in pregnancy-related anxiety and depressive symptoms during pregnancy were tested. Multiple logistic regression analysis was used to determine a predictive model for preterm birth. We then determined if the influence of perceived stress could moderate or mediate the effect of depressive symptoms on preterm birth.<h4>Results</h4>Changes in pregnancy-related anxiety (OR = 1.1, CI 0.97-1.17, p = 0.167) and depressive symptoms (OR = 0.9, CI 0.85-1.03, p = 0.179) were insignificant as predictors of preterm birth after adjusting for the effects of maternal education and family type. When perceived stress was added into the model, we found that changes in depressive symptoms became marginally significant after adjusting for covariates (OR = 0.9, CI 0.82-1.01, p = 0.082). After adjusting for the mediation effect of change in perceived stress, the effect of change in depressive symptoms on preterm birth were marginally significant after adjusting for covariates. Among six different dimensions of pregnancy-related anxiety, mother's concerns about fetal health showed a trend towards being predictive of preterm birth (OR = 1.3, CI 0.97-1.72, p = 0.078).<h4>Conclusions</h4>There may be a relationship between perceived stress and antenatal depressive symptoms and preterm birth. This is the first study of its kind to be conducted in Pakistan. Further research is required to validate these results.
format	article
author	Sharifa Lalani Aliyah Dosani Ntonghanwah Forcheh Shahirose Sadrudin Premji Sana Siddiqui Kiran Shaikh Ayesha Mian Ilona S Yim Maternal-infant Global Health Team (MiGHT) Collaborators in Research
author_facet	Sharifa Lalani Aliyah Dosani Ntonghanwah Forcheh Shahirose Sadrudin Premji Sana Siddiqui Kiran Shaikh Ayesha Mian Ilona S Yim Maternal-infant Global Health Team (MiGHT) Collaborators in Research
author_sort	Sharifa Lalani
title	Perceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: A pilot observational cohort study.
title_short	Perceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: A pilot observational cohort study.
title_full	Perceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: A pilot observational cohort study.
title_fullStr	Perceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: A pilot observational cohort study.
title_full_unstemmed	Perceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: A pilot observational cohort study.
title_sort	perceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: a pilot observational cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/fa45e383832a47b4be2f20d0357b6e5c
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Perceived stress may mediate the relationship between antenatal depressive symptoms and preterm birth: A pilot observational cohort study.

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