Combination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer

The aim of the study was to prove the efficacy of the treatment regimen for patients with colorectal cancer with metastatic liver involvement. The regimen included a combination of colon and liver resection, methods of local destruction and chemotherapy. There were 126 patients with colon cancer and...

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Autores principales:	A. S. Zagainov, R. I. Rasulov, A. V. Shelekhov, R. A. Zubkov, V. V. Dvornichenko
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	colorectal cancer metastatic liver disease chemoembolization hepatic resection Science Q
Acceso en línea:	https://doaj.org/article/fa4c2541c5f6407abb8d2a82e71f61c1
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spelling	oai:doaj.org-article:fa4c2541c5f6407abb8d2a82e71f61c12021-11-23T06:14:37ZCombination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer2541-94202587-959610.12737/article_59f035f8bc7ad1.15216742https://doaj.org/article/fa4c2541c5f6407abb8d2a82e71f61c12017-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/382https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The aim of the study was to prove the efficacy of the treatment regimen for patients with colorectal cancer with metastatic liver involvement. The regimen included a combination of colon and liver resection, methods of local destruction and chemotherapy. There were 126 patients with colon cancer and metastases in the liver involved in the study. All tumors were adenocarcinomas of the intestinal type. Metastases in the liver affected both lobes of the liver. In the main group (64 patients), resection of the large intestine and liver resection were carried out. During the operation, radiofrequency ablation of the remaining metastases and chemoembolization of the portal vein were performed. In the postoperative period, systemic chemotherapy and chemoembolization of the hepatic artery were prescribed. In the control group (62 patients), surgery was performed on the large intestine and systemic chemotherapy was performed. Complications of the operation occurred in 18 patients (28.1 %) in the main group and 10 in patients (16.1 %) in the control group (p = 0.004). Median disease-free survival in the main group was 9.01 months, in the control group - 5.01 months (p = 0.001). Median overall survival in the main group was 13.8 months, in the control group - 9.8 months (p = 0.004). One-year overall survival in the main group was 60.93 %, in the control group - 41.93 %, two-year in the main group -17.18 %, in the control group - 6.45 %. In the control group, there were no three years survivals, and in the main group, the three-year overall survival was 4.68 %.A. S. ZagainovR. I. RasulovA. V. ShelekhovR. A. ZubkovV. V. DvornichenkoScientific Сentre for Family Health and Human Reproduction Problemsarticlecolorectal cancermetastatic liver diseasechemoembolizationhepatic resectionScienceQRUActa Biomedica Scientifica, Vol 2, Iss 3, Pp 14-17 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	colorectal cancer metastatic liver disease chemoembolization hepatic resection Science Q
spellingShingle	colorectal cancer metastatic liver disease chemoembolization hepatic resection Science Q A. S. Zagainov R. I. Rasulov A. V. Shelekhov R. A. Zubkov V. V. Dvornichenko Combination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer
description	The aim of the study was to prove the efficacy of the treatment regimen for patients with colorectal cancer with metastatic liver involvement. The regimen included a combination of colon and liver resection, methods of local destruction and chemotherapy. There were 126 patients with colon cancer and metastases in the liver involved in the study. All tumors were adenocarcinomas of the intestinal type. Metastases in the liver affected both lobes of the liver. In the main group (64 patients), resection of the large intestine and liver resection were carried out. During the operation, radiofrequency ablation of the remaining metastases and chemoembolization of the portal vein were performed. In the postoperative period, systemic chemotherapy and chemoembolization of the hepatic artery were prescribed. In the control group (62 patients), surgery was performed on the large intestine and systemic chemotherapy was performed. Complications of the operation occurred in 18 patients (28.1 %) in the main group and 10 in patients (16.1 %) in the control group (p = 0.004). Median disease-free survival in the main group was 9.01 months, in the control group - 5.01 months (p = 0.001). Median overall survival in the main group was 13.8 months, in the control group - 9.8 months (p = 0.004). One-year overall survival in the main group was 60.93 %, in the control group - 41.93 %, two-year in the main group -17.18 %, in the control group - 6.45 %. In the control group, there were no three years survivals, and in the main group, the three-year overall survival was 4.68 %.
format	article
author	A. S. Zagainov R. I. Rasulov A. V. Shelekhov R. A. Zubkov V. V. Dvornichenko
author_facet	A. S. Zagainov R. I. Rasulov A. V. Shelekhov R. A. Zubkov V. V. Dvornichenko
author_sort	A. S. Zagainov
title	Combination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer
title_short	Combination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer
title_full	Combination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer
title_fullStr	Combination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer
title_full_unstemmed	Combination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer
title_sort	combination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/fa4c2541c5f6407abb8d2a82e71f61c1
work_keys_str_mv	AT aszagainov combinationofchemoembolizationwithhepaticresectionandmethodsoflocaldestructionincomplextreatmentofcolorectalcancer AT rirasulov combinationofchemoembolizationwithhepaticresectionandmethodsoflocaldestructionincomplextreatmentofcolorectalcancer AT avshelekhov combinationofchemoembolizationwithhepaticresectionandmethodsoflocaldestructionincomplextreatmentofcolorectalcancer AT razubkov combinationofchemoembolizationwithhepaticresectionandmethodsoflocaldestructionincomplextreatmentofcolorectalcancer AT vvdvornichenko combinationofchemoembolizationwithhepaticresectionandmethodsoflocaldestructionincomplextreatmentofcolorectalcancer
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Combination of chemoembolization with hepatic resection and methods of local destruction in complex treatment of colorectal cancer

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