Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.

Invariant NKT cells are innate lymphocytes with a broad tissue distribution. Here we demonstrate that iNKT cells reside in the central nervous system (CNS) in the absence of inflammation. Their presence in the CNS dramatically augments following inoculation of C57Bl/6 mice with the neurotropic Theil...

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Autores principales:	Lennart T Mars, Magali Mas, Lucie Beaudoin, Jan Bauer, Maria Leite-de-Moraes, Agnès Lehuen, Jean-Francois Bureau, Roland S Liblau
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/fa4d4249a3264668a5eeef48e6381af2
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spelling	oai:doaj.org-article:fa4d4249a3264668a5eeef48e6381af22021-11-18T08:34:45ZInvariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.1932-620310.1371/journal.pone.0087717https://doaj.org/article/fa4d4249a3264668a5eeef48e6381af22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498175/?tool=EBIhttps://doaj.org/toc/1932-6203Invariant NKT cells are innate lymphocytes with a broad tissue distribution. Here we demonstrate that iNKT cells reside in the central nervous system (CNS) in the absence of inflammation. Their presence in the CNS dramatically augments following inoculation of C57Bl/6 mice with the neurotropic Theiler's murine encephalomyelitis virus (TMEV). At the peak of inflammation the cellular infiltrate comprises 45,000 iNKT cells for 1250 CD8 T cells specific for the immunodominant TMEV epitope. To study the interaction between these two T cell subsets, we infected both iNKT cell deficient Jα18(-/-) mice and iNKT cell enriched Vα14 transgenic mice with TMEV. The CD8 T cell response readily cleared TMEV infection in the iNKT cell deficient mice. However, in the iNKT cell enriched mice TMEV infection persisted and was associated with significant mortality. This was caused by the inhibition of the CD8 T cell response in the cervical lymph nodes and spleen after T cell priming. Taken together we demonstrate that iNKT cells reside in the CNS in the absence of inflammation and that their enrichment is associated with the inhibition of the anti-viral CD8 T cell response and an augmented mortality during acute encephalomyelitis.Lennart T MarsMagali MasLucie BeaudoinJan BauerMaria Leite-de-MoraesAgnès LehuenJean-Francois BureauRoland S LiblauPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e87717 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lennart T Mars Magali Mas Lucie Beaudoin Jan Bauer Maria Leite-de-Moraes Agnès Lehuen Jean-Francois Bureau Roland S Liblau Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.
description	Invariant NKT cells are innate lymphocytes with a broad tissue distribution. Here we demonstrate that iNKT cells reside in the central nervous system (CNS) in the absence of inflammation. Their presence in the CNS dramatically augments following inoculation of C57Bl/6 mice with the neurotropic Theiler's murine encephalomyelitis virus (TMEV). At the peak of inflammation the cellular infiltrate comprises 45,000 iNKT cells for 1250 CD8 T cells specific for the immunodominant TMEV epitope. To study the interaction between these two T cell subsets, we infected both iNKT cell deficient Jα18(-/-) mice and iNKT cell enriched Vα14 transgenic mice with TMEV. The CD8 T cell response readily cleared TMEV infection in the iNKT cell deficient mice. However, in the iNKT cell enriched mice TMEV infection persisted and was associated with significant mortality. This was caused by the inhibition of the CD8 T cell response in the cervical lymph nodes and spleen after T cell priming. Taken together we demonstrate that iNKT cells reside in the CNS in the absence of inflammation and that their enrichment is associated with the inhibition of the anti-viral CD8 T cell response and an augmented mortality during acute encephalomyelitis.
format	article
author	Lennart T Mars Magali Mas Lucie Beaudoin Jan Bauer Maria Leite-de-Moraes Agnès Lehuen Jean-Francois Bureau Roland S Liblau
author_facet	Lennart T Mars Magali Mas Lucie Beaudoin Jan Bauer Maria Leite-de-Moraes Agnès Lehuen Jean-Francois Bureau Roland S Liblau
author_sort	Lennart T Mars
title	Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.
title_short	Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.
title_full	Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.
title_fullStr	Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.
title_full_unstemmed	Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.
title_sort	invariant nkt cells regulate the cd8 t cell response during theiler's virus infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/fa4d4249a3264668a5eeef48e6381af2
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Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.

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