Designed folding pathway of modular coiled-coil-based proteins

Coiled-coil protein origami (CCPO) is a strategy for the design of polyhedral cage-shaped protein folds based on coiled-coil (CC) dimer-forming peptides. Here, the authors show that CCPO proteins fold in a multistep process governed by the spatial distance between CC modules in the primary sequence...

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Autores principales:	Jana Aupič, Žiga Strmšek, Fabio Lapenta, David Pahovnik, Tomaž Pisanski, Igor Drobnak, Ajasja Ljubetič, Roman Jerala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa4fbd33eafd4cd298224a301d7d0ce4
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spelling	oai:doaj.org-article:fa4fbd33eafd4cd298224a301d7d0ce42021-12-02T14:26:59ZDesigned folding pathway of modular coiled-coil-based proteins10.1038/s41467-021-21185-52041-1723https://doaj.org/article/fa4fbd33eafd4cd298224a301d7d0ce42021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21185-5https://doaj.org/toc/2041-1723Coiled-coil protein origami (CCPO) is a strategy for the design of polyhedral cage-shaped protein folds based on coiled-coil (CC) dimer-forming peptides. Here, the authors show that CCPO proteins fold in a multistep process governed by the spatial distance between CC modules in the primary sequence and subsequent folding intermediates, which enables the use of identical CC modules for the CCPO tetrahedron design.Jana AupičŽiga StrmšekFabio LapentaDavid PahovnikTomaž PisanskiIgor DrobnakAjasja LjubetičRoman JeralaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jana Aupič Žiga Strmšek Fabio Lapenta David Pahovnik Tomaž Pisanski Igor Drobnak Ajasja Ljubetič Roman Jerala Designed folding pathway of modular coiled-coil-based proteins
description	Coiled-coil protein origami (CCPO) is a strategy for the design of polyhedral cage-shaped protein folds based on coiled-coil (CC) dimer-forming peptides. Here, the authors show that CCPO proteins fold in a multistep process governed by the spatial distance between CC modules in the primary sequence and subsequent folding intermediates, which enables the use of identical CC modules for the CCPO tetrahedron design.
format	article
author	Jana Aupič Žiga Strmšek Fabio Lapenta David Pahovnik Tomaž Pisanski Igor Drobnak Ajasja Ljubetič Roman Jerala
author_facet	Jana Aupič Žiga Strmšek Fabio Lapenta David Pahovnik Tomaž Pisanski Igor Drobnak Ajasja Ljubetič Roman Jerala
author_sort	Jana Aupič
title	Designed folding pathway of modular coiled-coil-based proteins
title_short	Designed folding pathway of modular coiled-coil-based proteins
title_full	Designed folding pathway of modular coiled-coil-based proteins
title_fullStr	Designed folding pathway of modular coiled-coil-based proteins
title_full_unstemmed	Designed folding pathway of modular coiled-coil-based proteins
title_sort	designed folding pathway of modular coiled-coil-based proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa4fbd33eafd4cd298224a301d7d0ce4
work_keys_str_mv	AT janaaupic designedfoldingpathwayofmodularcoiledcoilbasedproteins AT zigastrmsek designedfoldingpathwayofmodularcoiledcoilbasedproteins AT fabiolapenta designedfoldingpathwayofmodularcoiledcoilbasedproteins AT davidpahovnik designedfoldingpathwayofmodularcoiledcoilbasedproteins AT tomazpisanski designedfoldingpathwayofmodularcoiledcoilbasedproteins AT igordrobnak designedfoldingpathwayofmodularcoiledcoilbasedproteins AT ajasjaljubetic designedfoldingpathwayofmodularcoiledcoilbasedproteins AT romanjerala designedfoldingpathwayofmodularcoiledcoilbasedproteins
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Designed folding pathway of modular coiled-coil-based proteins

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