Impact of Andropause on Multiple Sclerosis

Andropause results from the natural decrease in testosterone levels that occurs with age. In contrast to menopause, which is a universal, well-characterized process associated with absolute gonadal failure, andropause ensues after gradual decline of both hypothalamic-pituitary-gonadal axis activity,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria C. Ysrraelit, Jorge Correale
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	andropause testosterone aging sex hormones multiple sclerosis Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/fa51307753d743f89ed150b8abd1deca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fa51307753d743f89ed150b8abd1deca
record_format	dspace
spelling	oai:doaj.org-article:fa51307753d743f89ed150b8abd1deca2021-11-05T08:37:06ZImpact of Andropause on Multiple Sclerosis1664-229510.3389/fneur.2021.766308https://doaj.org/article/fa51307753d743f89ed150b8abd1deca2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.766308/fullhttps://doaj.org/toc/1664-2295Andropause results from the natural decrease in testosterone levels that occurs with age. In contrast to menopause, which is a universal, well-characterized process associated with absolute gonadal failure, andropause ensues after gradual decline of both hypothalamic-pituitary-gonadal axis activity, as well as of testicular function, a process which usually develops over a period of many years. Increasing evidence on greater risk of Multiple sclerosis (MS) associated with lower testosterone levels is being reported. Likewise, epidemiological studies have shown a later age of onset of MS in men, relative to women, which could perhaps respond to the decline in protective testosterone levels. In this review, we will discuss the role of androgens in the development and function of the innate and adaptive immune response, as well as in neuroprotective mechanisms relevant to MS. Testosterone effects observed in different animal models and in epidemiological studies in humans will be discussed, as well as their correlation with physical disability and cognitive function levels. Finally, published and ongoing clinical trials exploring the role of androgens, particularly at key stages of sexual maturation, will be reviewed.Maria C. YsrraelitJorge CorrealeFrontiers Media S.A.articleandropausetestosteroneagingsex hormonesmultiple sclerosisNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	andropause testosterone aging sex hormones multiple sclerosis Neurology. Diseases of the nervous system RC346-429
spellingShingle	andropause testosterone aging sex hormones multiple sclerosis Neurology. Diseases of the nervous system RC346-429 Maria C. Ysrraelit Jorge Correale Impact of Andropause on Multiple Sclerosis
description	Andropause results from the natural decrease in testosterone levels that occurs with age. In contrast to menopause, which is a universal, well-characterized process associated with absolute gonadal failure, andropause ensues after gradual decline of both hypothalamic-pituitary-gonadal axis activity, as well as of testicular function, a process which usually develops over a period of many years. Increasing evidence on greater risk of Multiple sclerosis (MS) associated with lower testosterone levels is being reported. Likewise, epidemiological studies have shown a later age of onset of MS in men, relative to women, which could perhaps respond to the decline in protective testosterone levels. In this review, we will discuss the role of androgens in the development and function of the innate and adaptive immune response, as well as in neuroprotective mechanisms relevant to MS. Testosterone effects observed in different animal models and in epidemiological studies in humans will be discussed, as well as their correlation with physical disability and cognitive function levels. Finally, published and ongoing clinical trials exploring the role of androgens, particularly at key stages of sexual maturation, will be reviewed.
format	article
author	Maria C. Ysrraelit Jorge Correale
author_facet	Maria C. Ysrraelit Jorge Correale
author_sort	Maria C. Ysrraelit
title	Impact of Andropause on Multiple Sclerosis
title_short	Impact of Andropause on Multiple Sclerosis
title_full	Impact of Andropause on Multiple Sclerosis
title_fullStr	Impact of Andropause on Multiple Sclerosis
title_full_unstemmed	Impact of Andropause on Multiple Sclerosis
title_sort	impact of andropause on multiple sclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/fa51307753d743f89ed150b8abd1deca
work_keys_str_mv	AT mariacysrraelit impactofandropauseonmultiplesclerosis AT jorgecorreale impactofandropauseonmultiplesclerosis
_version_	1718444507339423744

Impact of Andropause on Multiple Sclerosis

Ejemplares similares