Uncertainty of leukoencephalopathies: a case report

Abstract Background Adult-onset leukoencephalopathies are a group of heterogeneous disorders characterized by white matter abnormalities. Leukoencephalopathy is usually encountered in children, but here we report a case with adult-onset leukoencephalopathy. Also, we explore this concept of uncertain...

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Autores principales:	Mohamed A. Taha, T. Scott Diesing
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Adult-onset leukoencephalopathies White matter lesions Rapidly progressive dementia Medical uncertainty Medicine R
Acceso en línea:	https://doaj.org/article/fa51fe1aab4945e791aac05e8b014228
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spelling	oai:doaj.org-article:fa51fe1aab4945e791aac05e8b0142282021-11-21T12:39:46ZUncertainty of leukoencephalopathies: a case report10.1186/s13256-021-03089-61752-1947https://doaj.org/article/fa51fe1aab4945e791aac05e8b0142282021-11-01T00:00:00Zhttps://doi.org/10.1186/s13256-021-03089-6https://doaj.org/toc/1752-1947Abstract Background Adult-onset leukoencephalopathies are a group of heterogeneous disorders characterized by white matter abnormalities. Leukoencephalopathy is usually encountered in children, but here we report a case with adult-onset leukoencephalopathy. Also, we explore this concept of uncertainty in medicine by discussing the approach to this case that has multiple possible etiologies. Case presentation A 70-year-old Caucasian male presented with a subacute onset of cognitive impairment and mood disturbances associated with behavioral changes. Neuroimaging demonstrated high-intensity lesions involving cerebral white matter. Progressive dementia and cognitive decline followed. Multiple possible etiologies are discussed based on the patient presentation and risk factors. Conclusion Adult-onset leukoencephalopathy can become a diagnostic challenge. Certain approaches need to be developed to explore the uncertainty of such conditions and to improve diagnostic yield.Mohamed A. TahaT. Scott DiesingBMCarticleAdult-onset leukoencephalopathiesWhite matter lesionsRapidly progressive dementiaMedical uncertaintyMedicineRENJournal of Medical Case Reports, Vol 15, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adult-onset leukoencephalopathies White matter lesions Rapidly progressive dementia Medical uncertainty Medicine R
spellingShingle	Adult-onset leukoencephalopathies White matter lesions Rapidly progressive dementia Medical uncertainty Medicine R Mohamed A. Taha T. Scott Diesing Uncertainty of leukoencephalopathies: a case report
description	Abstract Background Adult-onset leukoencephalopathies are a group of heterogeneous disorders characterized by white matter abnormalities. Leukoencephalopathy is usually encountered in children, but here we report a case with adult-onset leukoencephalopathy. Also, we explore this concept of uncertainty in medicine by discussing the approach to this case that has multiple possible etiologies. Case presentation A 70-year-old Caucasian male presented with a subacute onset of cognitive impairment and mood disturbances associated with behavioral changes. Neuroimaging demonstrated high-intensity lesions involving cerebral white matter. Progressive dementia and cognitive decline followed. Multiple possible etiologies are discussed based on the patient presentation and risk factors. Conclusion Adult-onset leukoencephalopathy can become a diagnostic challenge. Certain approaches need to be developed to explore the uncertainty of such conditions and to improve diagnostic yield.
format	article
author	Mohamed A. Taha T. Scott Diesing
author_facet	Mohamed A. Taha T. Scott Diesing
author_sort	Mohamed A. Taha
title	Uncertainty of leukoencephalopathies: a case report
title_short	Uncertainty of leukoencephalopathies: a case report
title_full	Uncertainty of leukoencephalopathies: a case report
title_fullStr	Uncertainty of leukoencephalopathies: a case report
title_full_unstemmed	Uncertainty of leukoencephalopathies: a case report
title_sort	uncertainty of leukoencephalopathies: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/fa51fe1aab4945e791aac05e8b014228
work_keys_str_mv	AT mohamedataha uncertaintyofleukoencephalopathiesacasereport AT tscottdiesing uncertaintyofleukoencephalopathiesacasereport
_version_	1718418922988896256

Uncertainty of leukoencephalopathies: a case report

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