Translational repression of NMD targets by GIGYF2 and EIF4E2.

Translation of messenger RNAs (mRNAs) with premature termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminating upstream of a splice site marked by an exon-junc...

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Autores principales: Boris Zinshteyn, Niladri K Sinha, Syed Usman Enam, Benjamin Koleske, Rachel Green
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/fa5279b562774fcdb51142e48baba02b
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