Regulation of Limbal Epithelial Stem Cells: Importance of the Niche

Limbal epithelial stem/progenitor cells (LSCs) reside in a niche that contains finely tuned balances of various signaling pathways including Wnt, Notch, BMP, Shh, YAP, and TGFβ. The activation or inhibition of these pathways is frequently dependent on the interactions of LSCs with various niche cell...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sarah Y. T. Robertson, JoAnn S. Roberts, Sophie X. Deng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cornea limbal stem cells signaling mechanotransduction extracellular matrix stem cell niche Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/fa5731dfa4664d54aab632cbbdb8117f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fa5731dfa4664d54aab632cbbdb8117f
record_format	dspace
spelling	oai:doaj.org-article:fa5731dfa4664d54aab632cbbdb8117f2021-11-11T17:23:46ZRegulation of Limbal Epithelial Stem Cells: Importance of the Niche10.3390/ijms2221119751422-00671661-6596https://doaj.org/article/fa5731dfa4664d54aab632cbbdb8117f2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11975https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Limbal epithelial stem/progenitor cells (LSCs) reside in a niche that contains finely tuned balances of various signaling pathways including Wnt, Notch, BMP, Shh, YAP, and TGFβ. The activation or inhibition of these pathways is frequently dependent on the interactions of LSCs with various niche cell types and extracellular substrates. In addition to receiving molecular signals from growth factors, cytokines, and other soluble molecules, LSCs also respond to their surrounding physical structure via mechanotransduction, interaction with the ECM, and interactions with other cell types. Damage to LSCs or their niche leads to limbal stem cell deficiency (LSCD). The field of LSCD treatment would greatly benefit from an understanding of the molecular regulation of LSCs in vitro and in vivo. This review synthesizes current literature around the niche factors and signaling pathways that influence LSC function. Future development of LSCD therapies should consider all these niche factors to achieve improved long-term restoration of the LSC population.Sarah Y. T. RobertsonJoAnn S. RobertsSophie X. DengMDPI AGarticlecornealimbal stem cellssignalingmechanotransductionextracellular matrixstem cell nicheBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11975, p 11975 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cornea limbal stem cells signaling mechanotransduction extracellular matrix stem cell niche Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cornea limbal stem cells signaling mechanotransduction extracellular matrix stem cell niche Biology (General) QH301-705.5 Chemistry QD1-999 Sarah Y. T. Robertson JoAnn S. Roberts Sophie X. Deng Regulation of Limbal Epithelial Stem Cells: Importance of the Niche
description	Limbal epithelial stem/progenitor cells (LSCs) reside in a niche that contains finely tuned balances of various signaling pathways including Wnt, Notch, BMP, Shh, YAP, and TGFβ. The activation or inhibition of these pathways is frequently dependent on the interactions of LSCs with various niche cell types and extracellular substrates. In addition to receiving molecular signals from growth factors, cytokines, and other soluble molecules, LSCs also respond to their surrounding physical structure via mechanotransduction, interaction with the ECM, and interactions with other cell types. Damage to LSCs or their niche leads to limbal stem cell deficiency (LSCD). The field of LSCD treatment would greatly benefit from an understanding of the molecular regulation of LSCs in vitro and in vivo. This review synthesizes current literature around the niche factors and signaling pathways that influence LSC function. Future development of LSCD therapies should consider all these niche factors to achieve improved long-term restoration of the LSC population.
format	article
author	Sarah Y. T. Robertson JoAnn S. Roberts Sophie X. Deng
author_facet	Sarah Y. T. Robertson JoAnn S. Roberts Sophie X. Deng
author_sort	Sarah Y. T. Robertson
title	Regulation of Limbal Epithelial Stem Cells: Importance of the Niche
title_short	Regulation of Limbal Epithelial Stem Cells: Importance of the Niche
title_full	Regulation of Limbal Epithelial Stem Cells: Importance of the Niche
title_fullStr	Regulation of Limbal Epithelial Stem Cells: Importance of the Niche
title_full_unstemmed	Regulation of Limbal Epithelial Stem Cells: Importance of the Niche
title_sort	regulation of limbal epithelial stem cells: importance of the niche
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fa5731dfa4664d54aab632cbbdb8117f
work_keys_str_mv	AT sarahytrobertson regulationoflimbalepithelialstemcellsimportanceoftheniche AT joannsroberts regulationoflimbalepithelialstemcellsimportanceoftheniche AT sophiexdeng regulationoflimbalepithelialstemcellsimportanceoftheniche
_version_	1718432155791523840

Regulation of Limbal Epithelial Stem Cells: Importance of the Niche

Ejemplares similares