Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function

Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function

Abstract Parkinson’s disease (PD) is characterised by the degeneration of A9 dopaminergic neurons and the pathological accumulation of alpha-synuclein. The p.A30P SNCA mutation generates the pathogenic form of the alpha-synuclein protein causing an autosomal-dominant form of PD. There are limited st...

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Autores principales: Peter A. Barbuti, Jochen Ohnmacht, Bruno F. R. Santos, Paul M. Antony, François Massart, Gérald Cruciani, Claire M. Dording, Lukas Pavelka, Nicolas Casadei, Yong-Jun Kwon, Rejko Krüger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fa5d1e8ffb404e52b22f63112205442d
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