Integrin CD11b activation drives anti-tumor innate immunity

Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacolog...

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Autores principales:	Michael C. Schmid, Samia Q. Khan, Megan M. Kaneda, Paulina Pathria, Ryan Shepard, Tiani L. Louis, Sudarshan Anand, Gyunghwi Woo, Chris Leem, M. Hafeez Faridi, Terese Geraghty, Anugraha Rajagopalan, Seema Gupta, Mansoor Ahmed, Roberto I. Vazquez-Padron, David A. Cheresh, Vineet Gupta, Judith A. Varner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa609fba06764331883a98cafef892a0
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spelling	oai:doaj.org-article:fa609fba06764331883a98cafef892a02021-12-02T16:49:37ZIntegrin CD11b activation drives anti-tumor innate immunity10.1038/s41467-018-07387-42041-1723https://doaj.org/article/fa609fba06764331883a98cafef892a02018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07387-4https://doaj.org/toc/2041-1723Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacological activation of CD11b enhances survival in mouse models of cancer.Michael C. SchmidSamia Q. KhanMegan M. KanedaPaulina PathriaRyan ShepardTiani L. LouisSudarshan AnandGyunghwi WooChris LeemM. Hafeez FaridiTerese GeraghtyAnugraha RajagopalanSeema GuptaMansoor AhmedRoberto I. Vazquez-PadronDavid A. ChereshVineet GuptaJudith A. VarnerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael C. Schmid Samia Q. Khan Megan M. Kaneda Paulina Pathria Ryan Shepard Tiani L. Louis Sudarshan Anand Gyunghwi Woo Chris Leem M. Hafeez Faridi Terese Geraghty Anugraha Rajagopalan Seema Gupta Mansoor Ahmed Roberto I. Vazquez-Padron David A. Cheresh Vineet Gupta Judith A. Varner Integrin CD11b activation drives anti-tumor innate immunity
description	Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacological activation of CD11b enhances survival in mouse models of cancer.
format	article
author	Michael C. Schmid Samia Q. Khan Megan M. Kaneda Paulina Pathria Ryan Shepard Tiani L. Louis Sudarshan Anand Gyunghwi Woo Chris Leem M. Hafeez Faridi Terese Geraghty Anugraha Rajagopalan Seema Gupta Mansoor Ahmed Roberto I. Vazquez-Padron David A. Cheresh Vineet Gupta Judith A. Varner
author_facet	Michael C. Schmid Samia Q. Khan Megan M. Kaneda Paulina Pathria Ryan Shepard Tiani L. Louis Sudarshan Anand Gyunghwi Woo Chris Leem M. Hafeez Faridi Terese Geraghty Anugraha Rajagopalan Seema Gupta Mansoor Ahmed Roberto I. Vazquez-Padron David A. Cheresh Vineet Gupta Judith A. Varner
author_sort	Michael C. Schmid
title	Integrin CD11b activation drives anti-tumor innate immunity
title_short	Integrin CD11b activation drives anti-tumor innate immunity
title_full	Integrin CD11b activation drives anti-tumor innate immunity
title_fullStr	Integrin CD11b activation drives anti-tumor innate immunity
title_full_unstemmed	Integrin CD11b activation drives anti-tumor innate immunity
title_sort	integrin cd11b activation drives anti-tumor innate immunity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/fa609fba06764331883a98cafef892a0
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Integrin CD11b activation drives anti-tumor innate immunity

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