Feed-forward regulation adaptively evolves via dynamics rather than topology when there is intrinsic noise

Feed‐forward loops (FFLs) can filter out noise, but whether their overrepresentation in GRNs reflects adaptive evolution for this function is debated. Here, the authors develop a null model of regulatory evolution and find that FFLs evolve readily under selection for the noise filtering function.

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Detalles Bibliográficos
Autores principales: Kun Xiong, Alex K. Lancaster, Mark L. Siegal, Joanna Masel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/fa643ad0636c418e840b324feb672761
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