Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix

This study was performed to appraise the biocompatibility of polyhedral oligomeric silsesquioxane (POSS)-grafted polyurethane (PU) nanocomposites as potential materials for muscle tissue renewal. POSS nanoparticles demonstrate effectual nucleation and cause noteworthy enhancement in mechanical and t...

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Autores principales:	Touseef Amna, Mallick Shamshi Hassan, Mohamed H. El-Newehy, Tariq Alghamdi, Meera Moydeen Abdulhameed, Myung-Seob Khil
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polyhedral oligomeric silsesquioxanes polyurethane muscle cells nanofibers Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/fa64fd79be6d4c10b189bbfc7565653c
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spelling	oai:doaj.org-article:fa64fd79be6d4c10b189bbfc7565653c2021-11-25T18:31:15ZBiocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix10.3390/nano111129662079-4991https://doaj.org/article/fa64fd79be6d4c10b189bbfc7565653c2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2966https://doaj.org/toc/2079-4991This study was performed to appraise the biocompatibility of polyhedral oligomeric silsesquioxane (POSS)-grafted polyurethane (PU) nanocomposites as potential materials for muscle tissue renewal. POSS nanoparticles demonstrate effectual nucleation and cause noteworthy enhancement in mechanical and thermal steadiness as well as biocompatibility of resultant composites. Electrospun, well-aligned, POSS-grafted PU nanofibers were prepared. Physicochemical investigation was conducted using several experimental techniques, including scanning electron microscopy, energy dispersive X-ray spectroscopy, electron probe microanalysis, Fourier transform infrared spectroscopy, and X-ray diffraction pattern. Adding POSS molecules to PU did not influence the processability and morphology of the nanocomposite; however, we observed an obvious mean reduction in fiber diameter, which amplified specific areas of the POSS-grafted PU. Prospective biomedical uses of nanocomposite were also appraised for myoblast cell differentiation in vitro. Little is known about C2C12 cellular responses to PU, and there is no information regarding their interaction with POSS-grafted PU. The antimicrobial potential, anchorage, proliferation, communication, and differentiation of C2C12 on PU and POSS-grafted PU were investigated in this study. In conclusion, preliminary nanocomposites depicted superior cell adhesion due to the elevated free energy of POSS molecules and anti-inflammatory potential. These nanofibers were non-hazardous, and, as such, biomimetic scaffolds show high potential for cellular studies and muscle regeneration.Touseef AmnaMallick Shamshi HassanMohamed H. El-NewehyTariq AlghamdiMeera Moydeen AbdulhameedMyung-Seob KhilMDPI AGarticlepolyhedral oligomeric silsesquioxanespolyurethanemuscle cellsnanofibersChemistryQD1-999ENNanomaterials, Vol 11, Iss 2966, p 2966 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyhedral oligomeric silsesquioxanes polyurethane muscle cells nanofibers Chemistry QD1-999
spellingShingle	polyhedral oligomeric silsesquioxanes polyurethane muscle cells nanofibers Chemistry QD1-999 Touseef Amna Mallick Shamshi Hassan Mohamed H. El-Newehy Tariq Alghamdi Meera Moydeen Abdulhameed Myung-Seob Khil Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix
description	This study was performed to appraise the biocompatibility of polyhedral oligomeric silsesquioxane (POSS)-grafted polyurethane (PU) nanocomposites as potential materials for muscle tissue renewal. POSS nanoparticles demonstrate effectual nucleation and cause noteworthy enhancement in mechanical and thermal steadiness as well as biocompatibility of resultant composites. Electrospun, well-aligned, POSS-grafted PU nanofibers were prepared. Physicochemical investigation was conducted using several experimental techniques, including scanning electron microscopy, energy dispersive X-ray spectroscopy, electron probe microanalysis, Fourier transform infrared spectroscopy, and X-ray diffraction pattern. Adding POSS molecules to PU did not influence the processability and morphology of the nanocomposite; however, we observed an obvious mean reduction in fiber diameter, which amplified specific areas of the POSS-grafted PU. Prospective biomedical uses of nanocomposite were also appraised for myoblast cell differentiation in vitro. Little is known about C2C12 cellular responses to PU, and there is no information regarding their interaction with POSS-grafted PU. The antimicrobial potential, anchorage, proliferation, communication, and differentiation of C2C12 on PU and POSS-grafted PU were investigated in this study. In conclusion, preliminary nanocomposites depicted superior cell adhesion due to the elevated free energy of POSS molecules and anti-inflammatory potential. These nanofibers were non-hazardous, and, as such, biomimetic scaffolds show high potential for cellular studies and muscle regeneration.
format	article
author	Touseef Amna Mallick Shamshi Hassan Mohamed H. El-Newehy Tariq Alghamdi Meera Moydeen Abdulhameed Myung-Seob Khil
author_facet	Touseef Amna Mallick Shamshi Hassan Mohamed H. El-Newehy Tariq Alghamdi Meera Moydeen Abdulhameed Myung-Seob Khil
author_sort	Touseef Amna
title	Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix
title_short	Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix
title_full	Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix
title_fullStr	Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix
title_full_unstemmed	Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix
title_sort	biocompatibility computation of muscle cells on polyhedral oligomeric silsesquioxane-grafted polyurethane nanomatrix
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/fa64fd79be6d4c10b189bbfc7565653c
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Biocompatibility Computation of Muscle Cells on Polyhedral Oligomeric Silsesquioxane-Grafted Polyurethane Nanomatrix

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