An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics data to show that KIF4A and WDR62 drive aggressive...

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Autores principales: Rajdeep Das, Martin Sjöström, Raunak Shrestha, Christopher Yogodzinski, Emily A. Egusa, Lisa N. Chesner, William S. Chen, Jonathan Chou, Donna K. Dang, Jason T. Swinderman, Alex Ge, Junjie T. Hua, Shaheen Kabir, David A. Quigley, Eric J. Small, Alan Ashworth, Felix Y. Feng, Luke A. Gilbert
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fa65632946e846318209a6540b59b6ba
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spelling oai:doaj.org-article:fa65632946e846318209a6540b59b6ba2021-12-02T16:31:04ZAn integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer10.1038/s41467-021-24919-72041-1723https://doaj.org/article/fa65632946e846318209a6540b59b6ba2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24919-7https://doaj.org/toc/2041-1723It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics data to show that KIF4A and WDR62 drive aggressive prostate cancer phenotypes.Rajdeep DasMartin SjöströmRaunak ShresthaChristopher YogodzinskiEmily A. EgusaLisa N. ChesnerWilliam S. ChenJonathan ChouDonna K. DangJason T. SwindermanAlex GeJunjie T. HuaShaheen KabirDavid A. QuigleyEric J. SmallAlan AshworthFelix Y. FengLuke A. GilbertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rajdeep Das
Martin Sjöström
Raunak Shrestha
Christopher Yogodzinski
Emily A. Egusa
Lisa N. Chesner
William S. Chen
Jonathan Chou
Donna K. Dang
Jason T. Swinderman
Alex Ge
Junjie T. Hua
Shaheen Kabir
David A. Quigley
Eric J. Small
Alan Ashworth
Felix Y. Feng
Luke A. Gilbert
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
description It is hypothesized that there are a number of tumor specific driver genes for metastatic prostate cancer. Here, the authors perform genome-wide CRISPRi screens and integrate these data with metastatic prostate cancer functional and clinical genomics data to show that KIF4A and WDR62 drive aggressive prostate cancer phenotypes.
format article
author Rajdeep Das
Martin Sjöström
Raunak Shrestha
Christopher Yogodzinski
Emily A. Egusa
Lisa N. Chesner
William S. Chen
Jonathan Chou
Donna K. Dang
Jason T. Swinderman
Alex Ge
Junjie T. Hua
Shaheen Kabir
David A. Quigley
Eric J. Small
Alan Ashworth
Felix Y. Feng
Luke A. Gilbert
author_facet Rajdeep Das
Martin Sjöström
Raunak Shrestha
Christopher Yogodzinski
Emily A. Egusa
Lisa N. Chesner
William S. Chen
Jonathan Chou
Donna K. Dang
Jason T. Swinderman
Alex Ge
Junjie T. Hua
Shaheen Kabir
David A. Quigley
Eric J. Small
Alan Ashworth
Felix Y. Feng
Luke A. Gilbert
author_sort Rajdeep Das
title An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
title_short An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
title_full An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
title_fullStr An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
title_full_unstemmed An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
title_sort integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/fa65632946e846318209a6540b59b6ba
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