Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication

Abstract The level of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative (TNBC) and HER2-positive breast cancers convey prognostic information. The importance of systemic immunity to local immunity is unknown in breast cancer. We previously demonstrated that histological alterations i...

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Autores principales:	Fangfang Liu, Thomas Hardiman, Kailiang Wu, Jelmar Quist, Patrycja Gazinska, Tony Ng, Arnie Purushotham, Roberto Salgado, Xiaojing Guo, Sarah E. Pinder, Anita Grigoriadis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/fa6779f79a31447c9a8b4c88579bba41
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spelling	oai:doaj.org-article:fa6779f79a31447c9a8b4c88579bba412021-12-02T15:39:42ZSystemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication10.1038/s41523-021-00292-y2374-4677https://doaj.org/article/fa6779f79a31447c9a8b4c88579bba412021-07-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00292-yhttps://doaj.org/toc/2374-4677Abstract The level of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative (TNBC) and HER2-positive breast cancers convey prognostic information. The importance of systemic immunity to local immunity is unknown in breast cancer. We previously demonstrated that histological alterations in axillary lymph nodes (LNs) carry clinical relevance. Here, we capture local immune responses by scoring TILs at the primary tumor and systemic immune responses by recording the formation of secondary follicles, also known as germinal centers, in 2,857 cancer-free and involved axillary LNs on haematoxylin and eosin (H&E) stained sections from a retrospective cohort of 161 LN-positive triple-negative and HER2-positive breast cancer patients. Our data demonstrate that the number of germinal center formations across all cancer-free LNs, similar to high levels of TILs, is associated with a good prognosis in low TILs TNBC. This highlights the importance of assessing both primary and LN immune responses for prognostication and for future breast cancer research.Fangfang LiuThomas HardimanKailiang WuJelmar QuistPatrycja GazinskaTony NgArnie PurushothamRoberto SalgadoXiaojing GuoSarah E. PinderAnita GrigoriadisNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fangfang Liu Thomas Hardiman Kailiang Wu Jelmar Quist Patrycja Gazinska Tony Ng Arnie Purushotham Roberto Salgado Xiaojing Guo Sarah E. Pinder Anita Grigoriadis Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication
description	Abstract The level of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative (TNBC) and HER2-positive breast cancers convey prognostic information. The importance of systemic immunity to local immunity is unknown in breast cancer. We previously demonstrated that histological alterations in axillary lymph nodes (LNs) carry clinical relevance. Here, we capture local immune responses by scoring TILs at the primary tumor and systemic immune responses by recording the formation of secondary follicles, also known as germinal centers, in 2,857 cancer-free and involved axillary LNs on haematoxylin and eosin (H&E) stained sections from a retrospective cohort of 161 LN-positive triple-negative and HER2-positive breast cancer patients. Our data demonstrate that the number of germinal center formations across all cancer-free LNs, similar to high levels of TILs, is associated with a good prognosis in low TILs TNBC. This highlights the importance of assessing both primary and LN immune responses for prognostication and for future breast cancer research.
format	article
author	Fangfang Liu Thomas Hardiman Kailiang Wu Jelmar Quist Patrycja Gazinska Tony Ng Arnie Purushotham Roberto Salgado Xiaojing Guo Sarah E. Pinder Anita Grigoriadis
author_facet	Fangfang Liu Thomas Hardiman Kailiang Wu Jelmar Quist Patrycja Gazinska Tony Ng Arnie Purushotham Roberto Salgado Xiaojing Guo Sarah E. Pinder Anita Grigoriadis
author_sort	Fangfang Liu
title	Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication
title_short	Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication
title_full	Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication
title_fullStr	Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication
title_full_unstemmed	Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication
title_sort	systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa6779f79a31447c9a8b4c88579bba41
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Systemic immune reaction in axillary lymph nodes adds to tumor-infiltrating lymphocytes in triple-negative breast cancer prognostication

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