Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.
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Nature Portfolio
2021
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oai:doaj.org-article:fa68c802cf994295ba5c37913f6eb9772021-12-02T13:14:53ZMitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages10.1038/s41467-021-21617-22041-1723https://doaj.org/article/fa68c802cf994295ba5c37913f6eb9772021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21617-2https://doaj.org/toc/2041-1723IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory.Jennifer K. DowlingRemsha AfzalLinden J. GearingMariana P. Cervantes-SilvaStephanie AnnettGavin M. DavisChiara De SantiNadine AssmannKatja DettmerDaniel J. GoughGlenn R. BantugFidinny I. HamidFrances K. NallyConor P. DuffyAoife L. GormanAlex M. LiddicoatEd C. LavelleChristoph HessPeter J. OefnerDavid K. FinlayGavin P. DaveyTracy RobsonAnnie M. CurtisPaul J. HertzogBryan R. G. WilliamsClaire E. McCoyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
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Science Q Jennifer K. Dowling Remsha Afzal Linden J. Gearing Mariana P. Cervantes-Silva Stephanie Annett Gavin M. Davis Chiara De Santi Nadine Assmann Katja Dettmer Daniel J. Gough Glenn R. Bantug Fidinny I. Hamid Frances K. Nally Conor P. Duffy Aoife L. Gorman Alex M. Liddicoat Ed C. Lavelle Christoph Hess Peter J. Oefner David K. Finlay Gavin P. Davey Tracy Robson Annie M. Curtis Paul J. Hertzog Bryan R. G. Williams Claire E. McCoy Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages |
| description |
IL-10 can limit inflammation in part by inhibiting miR-155. Here the authors show how this axis induces mitochondrial arginase-2 to alter the mitochondrial dynamics and bioenergetics of macrophages and make these cells less pro-inflammatory. |
| format |
article |
| author |
Jennifer K. Dowling Remsha Afzal Linden J. Gearing Mariana P. Cervantes-Silva Stephanie Annett Gavin M. Davis Chiara De Santi Nadine Assmann Katja Dettmer Daniel J. Gough Glenn R. Bantug Fidinny I. Hamid Frances K. Nally Conor P. Duffy Aoife L. Gorman Alex M. Liddicoat Ed C. Lavelle Christoph Hess Peter J. Oefner David K. Finlay Gavin P. Davey Tracy Robson Annie M. Curtis Paul J. Hertzog Bryan R. G. Williams Claire E. McCoy |
| author_facet |
Jennifer K. Dowling Remsha Afzal Linden J. Gearing Mariana P. Cervantes-Silva Stephanie Annett Gavin M. Davis Chiara De Santi Nadine Assmann Katja Dettmer Daniel J. Gough Glenn R. Bantug Fidinny I. Hamid Frances K. Nally Conor P. Duffy Aoife L. Gorman Alex M. Liddicoat Ed C. Lavelle Christoph Hess Peter J. Oefner David K. Finlay Gavin P. Davey Tracy Robson Annie M. Curtis Paul J. Hertzog Bryan R. G. Williams Claire E. McCoy |
| author_sort |
Jennifer K. Dowling |
| title |
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages |
| title_short |
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages |
| title_full |
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages |
| title_fullStr |
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages |
| title_full_unstemmed |
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages |
| title_sort |
mitochondrial arginase-2 is essential for il-10 metabolic reprogramming of inflammatory macrophages |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/fa68c802cf994295ba5c37913f6eb977 |
| work_keys_str_mv |
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