Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption

Abstract Tissue inhibitor of metalloproteases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs) that regulate tissue extracellular matrix (ECM) turnover. TIMP4 is highly expressed in adipose tissue, its levels are further elevated following high-fat diet, but its role in obesity is unknown....

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Autores principales: Siva S. V. P. Sakamuri, Russell Watts, Abhijit Takawale, Xiuhua Wang, Samuel Hernandez-Anzaldo, Wesam Bahitham, Carlos Fernandez-Patron, Richard Lehner, Zamaneh Kassiri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/fa68f747eb244e7984495198cb3a085e
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