Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD

Hexanucleotide repeat expansion in the intron 1 of the C9ORF72 gene can cause amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). Here the authors use single molecule imaging to show nuclear export and translation of circular repeat-containing C9ORF72 intronic RNA.

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Bibliographic Details
Main Authors:	Shaopeng Wang, Malgorzata J. Latallo, Zhe Zhang, Bo Huang, Dmitriy G. Bobrovnikov, Daoyuan Dong, Nathan M. Livingston, Wilson Tjoeng, Lindsey R. Hayes, Jeffrey D. Rothstein, Lyle W. Ostrow, Bin Wu, Shuying Sun
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/fa693cbc636a4db9b4b2a4b8bdc7fe5c
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spelling	oai:doaj.org-article:fa693cbc636a4db9b4b2a4b8bdc7fe5c2021-12-02T16:27:56ZNuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD10.1038/s41467-021-25082-92041-1723https://doaj.org/article/fa693cbc636a4db9b4b2a4b8bdc7fe5c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25082-9https://doaj.org/toc/2041-1723Hexanucleotide repeat expansion in the intron 1 of the C9ORF72 gene can cause amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). Here the authors use single molecule imaging to show nuclear export and translation of circular repeat-containing C9ORF72 intronic RNA.Shaopeng WangMalgorzata J. LatalloZhe ZhangBo HuangDmitriy G. BobrovnikovDaoyuan DongNathan M. LivingstonWilson TjoengLindsey R. HayesJeffrey D. RothsteinLyle W. OstrowBin WuShuying SunNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaopeng Wang Malgorzata J. Latallo Zhe Zhang Bo Huang Dmitriy G. Bobrovnikov Daoyuan Dong Nathan M. Livingston Wilson Tjoeng Lindsey R. Hayes Jeffrey D. Rothstein Lyle W. Ostrow Bin Wu Shuying Sun Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD
description	Hexanucleotide repeat expansion in the intron 1 of the C9ORF72 gene can cause amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD). Here the authors use single molecule imaging to show nuclear export and translation of circular repeat-containing C9ORF72 intronic RNA.
format	article
author	Shaopeng Wang Malgorzata J. Latallo Zhe Zhang Bo Huang Dmitriy G. Bobrovnikov Daoyuan Dong Nathan M. Livingston Wilson Tjoeng Lindsey R. Hayes Jeffrey D. Rothstein Lyle W. Ostrow Bin Wu Shuying Sun
author_facet	Shaopeng Wang Malgorzata J. Latallo Zhe Zhang Bo Huang Dmitriy G. Bobrovnikov Daoyuan Dong Nathan M. Livingston Wilson Tjoeng Lindsey R. Hayes Jeffrey D. Rothstein Lyle W. Ostrow Bin Wu Shuying Sun
author_sort	Shaopeng Wang
title	Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD
title_short	Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD
title_full	Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD
title_fullStr	Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD
title_full_unstemmed	Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD
title_sort	nuclear export and translation of circular repeat-containing intronic rna in c9orf72-als/ftd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/fa693cbc636a4db9b4b2a4b8bdc7fe5c
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Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD

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